Attendees will learn about:

• Recent breakthroughs in PDE structure and regulation
• Compartmentalized signaling within macromolecular complexes
• Structural and mechanistic insights into cyclic nucleotide effectors and degraders
• Cutting-edge technologies for visualizing signaling networks
• The development of novel therapeutic strategies targeting cyclic nucleotide pathways

Program topics include:

• Recent advances in understanding the players in cyclic nucleotide signal transduction in nanodomains of cells
• Spatiotemporal regulation of cyclic nucleotide signaling
• Novel mechanisms of cyclic nucleotide signaling in intracellular compartments
• Cyclic nucleotide regulation of substance addiction
• PDEs in neurological disorders
• Cyclic nucleotide regulation of cardiovascular function in health and disease
• Cyclic nucleotide signaling and PDEs in metabolism, tissue remodeling and fibrosis

Workshops:  

Meet the Experts sessions designed to promote mentoring and discussion will focus on topics including: experimental design strategies for probing compartmentalized cAMP/cGMP signaling; best practices for pharmacological and genetic approaches to study PDE isoforms and signaling nanodomains; interpretation of cyclic nucleotide biosensor imaging and super-resolution methods; common pitfalls in PDE inhibitor studies; and translating basic cyclic nucleotide signaling discoveries into therapeutic opportunities.

A Career Development Workshop will feature representatives from academia, industry, and science administration describing their career paths and challenges, and giving advice to junior scientists on which skills to develop or which steps to take.