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The FASEB Journal August 2025 Issue Features Advances in Biomedical Research, Disease Mechanisms, and New Therapies
Friday, August 15, 2025The August 15, 2025 issue of The FASEB Journal (Volume 39, Issue 15) showcases a wide range of biomedical research spanning molecular mechanisms, disease pathogenesis, and potential therapeutic strategies. Highlights include insights into ferroptosis in mycotoxin toxicity, the role of lactate in addiction biology, estrogen’s interplay with aging in atherosclerosis, and novel approaches to combat neurodegenerative, cardiovascular, metabolic, and infectious diseases. This issue also features innovative studies on genetic underpinnings of recurrent pregnancy loss, immune regulation in autoimmune disorders, and emerging biotechnologies with translational potential—advancing our understanding of health and disease across the lifespan.
Review Articles
Role of Ferroptosis in the Redox Biology of Mycotoxins
Keyun Li et al.
The Role of Lactate in Drug Addiction
Ruiqi Chen et al.
Complex Interplay Between Estrogen and Aging via Lipid Metabolism and Inflammation Forms the Novel Treatment Strategies for Atherosclerosis
Yijun Xin et al.
Food Intake According to Clock Gene Polymorphisms: A Systematic Review
Laís Teixeira Campos et al.
Research Articles
The T3SS1 Effector VopR Requires the Rac1-Erk1/2 Axis to Inhibit the Host Immune Response to Vibrio parahaemolyticus
Yuying Cao et al.
Trio Exome Sequencing Reveal Paternal Transmission Bias and Novel Gene Loci in Recurrent Spontaneous Abortion
Honglei Duan et al.
Increased Dipeptidyl Peptidase-4 Promotes Adipose Inflammation and Dysfunction in Mice Under Chronic Stress
Meiping Zhang et al.
Rationally Designed Functionalized Phytochemical-Conjugated Fullerene Quantum Dots Inhibiting Viral Chaperone Activity and RNA-Dependent RNA Polymerase in Nipah Virus
Giridharan Loghanathan Malarvizhi and Jagadeesh Bayry
Nicotinamide Mononucleotide Alleviates Aging Defects in Hutchinson–Gilford Progeria Syndrome
Yuyan Xu et al.
Tumor Necrosis Factor Receptor Superfamily Member 12A Enhances Retinal Ganglion Cell Survival and Promotes Axon Regeneration
Xiaxue Chen and Guangyu Li
Immune Modulatory Effects of PD-1/PD-L1 in Myasthenia Gravis: Insights From Peripheral Blood Mononuclear Cell Analysis
Jianing Li et al.
ZMYM2-FLT3 Fusion Gene: Implications for Chromosomal Instability and Proliferation in Myeloid/Lymphoid Neoplasms
Ying Liang et al.
Hydronidone Alleviates Metabolic Dysfunction-Associated Fatty Liver Disease by Inhibiting CD36 Expression
Xin Luo et al.
Integrated Transcriptome and Metabolome Analysis Reveals a Disturbance in Antioxidant Metabolism Associated With the Progression of Bronchopulmonary Dysplasia
Xianxian Jia et al.
Cytokine-Induced Cytotoxicity and Extracellular Matrix Abnormalities in Hepatocytes Derived From RAD50-Interacting Protein 1-Deficient Induced Pluripotent Stem Cells
Yumeng Zhang et al.
FIH-1 Deletion in Intestinal Epithelial Cells Causes Radioprotection by Activating PI3K-AKT Pathway
Yuwei Yang et al.
UFMylation of BiP/GRP78 Is Crucial for Maintenance of Endoplasmic Reticulum Homeostasis
Zhu Li et al.
Hydrogen Sulfide Protects Erectile Function Through Stimulation of Antioxidant Defense in the Corpus Cavernosum: Insights From SG1002 Administration and Cystathionine γ-Lyase Knockout
Tooyib A. Azeez et al.
A Neutrophil Storage Pool in the Fetal Liver is the Principal Source of the Postnatal Neutrophil Surge
Ryo Ishiwata and Yuji Morimoto
HOXA5 Inhibits Microglia Pyroptosis in Cerebral Stroke by Regulating FTO-Mediated TMEM59 m6A Demethylation
Lin Mou et al.
Prostaglandin E2 and Progesterone Receptor Coordinately Regulate Primary Cilia for Proper Decidualization
Chih-Jhen Lee et al.
Paclitaxel Attenuates Atherosclerosis by Suppressing Macrophage Ferroptosis and Improving Lipid Metabolism via the Sirt1/Nrf2/GPX4 Pathway
Zhenghao Liu et al.
Tribulus terrestris L. Extract Alleviates Atherosclerosis by Suppressing TNF-α-Mediated Macrophage Inflammation
Zheng Yu-Qian et al.
The TBLR1/TBL1 Co-Factor Complex Acts as a Transcriptional Checkpoint in the Brown Adipose Tissue Response to Prolonged Cold Exposure
Sahika Cingir Köker et al.
SIRT6 Attenuates ER Stress-Associated Mucus Hypersecretion via Regulation of NRF2 in Asthma Models
Fen Liu et al.
Ribo-Seq Analysis-Based Elucidation of the Dynamic Translation Landscape of Yak Ovarian Tissues in Different Reproductive Stages
Liyan Hu et al.
Dopaminergic Neuron-Specific Tfam Knockout Links Inter-Organelle Miscommunication to Early-Onset Parkinsonism
Weiyan Shen et al.
Pathogen Profiling and Molecular Evaluation Along With In Silico Modeling of Voltage-Gated Sodium Channel Gene in Deltamethrin Exposed Haemaphysalis longicornis Ticks
Muhammad Kashif Obaid et al.
High-Fat Diet Impairs Translocation of Phosphatidylserine From Mitochondria-Associated Membranes (MAM) Into Mitochondria by the Conservative Mechanism From Fish to Tetrapod
Xiao-Hong Lai et al.
Blocking the ADAM9/ITGAV Pathway Ameliorates Sepsis-Induced Acute Lung Injury by Promoting Macrophage Efferocytosis
Long-Zhu Li et al.
The Ketone Body β-Hydroxybutyrate Mitigates the Ferroptosis of Alveolar Epithelial Cells Type II in Bleomycin-Induced Pulmonary Fibrosis
Jian Zhou et al.
Pharmacological but Not Physiological Levels of GDF15 and FGF21 Regulate Body Weight and Glycemic Control in Obese Mice
Sarah Engelbeen et al.
Nuclear Autoantigenic Sperm Protein Promotes Cardiac Regeneration and Repair Through Activating the PDGFRB/AKT Pathway
Hao Wang et al.
M2c Macrophages Mediate YAP1 to Promote Vascularized Bone Regeneration in Distraction Osteogenesis
Haifeng Liu et al.
DGAT1 Inhibition Enhances Olaparib-Induced Lipotoxic Apoptosis in Metastatic Castration-Resistant Prostate Cancer
Md. Niaz Morshed et al.
Integrated Microbiota–Bile Acid Analysis as Potential NonInvasive Biomarkers for Ulcerative Colitis Staging Diagnose
Tianyu He et al.
Research Letter
Myocardial Growth Response to Fetal Intralipid Infusion in Sheep
Kaliyah Iverson et al.