From Microbiota to Microgravity: What’s Inside The FASEB Journal’s Latest Issue
Tuesday, July 15, 2025
The 15 July 2025 issue (Vol. 39, Issue 13) of The FASEB Journal showcases a diverse collection of cutting-edge research and reviews spanning gut microbiota, aging in altered gravity, innovative therapeutic strategies, and the cellular mechanisms driving diseases from cardiovascular conditions to cancer. This issue's articles highlight advances in understanding collective cell migration, macrophage regulation, and the impacts of diet and microbiota on human health, while also exploring promising interventions for conditions like osteoporosis, neuroblastoma, endometriosis, and more. Together, these studies reflect the journal’s commitment to advancing knowledge across the biological and biomedical sciences.
REVIEW ARTICLES
Deciphering the Effect of Ginsenoside Rk3 on Gut Microbiota and Its Applications
Aging and Altered Gravity: A Cellular Perspective
Honokiol Targeting SIRT3: From Molecular Mechanisms to Therapeutic Opportunities
Dynamic Leader–Follower Hierarchies in Collective Cell Migration
Research Progress on the Regulation of Macrophages for Cardiovascular Diseases
Small Molecules as Regulators of Liquid–Liquid Phase Separation: Mechanisms and Strategies for New Drug Discovery
Food Additives: Emerging Detrimental Roles on Gut Health
RESEARCH ARTICLES
Resistance and Aerobic Preconditioning Delays Unloading-Induced Multisystemic Physiological Changes: The NEBULA Project
Skeletal Muscle Mitochondria Contain Nuclear-Encoded RNA Species Prior to and Following Adaptation to Exercise Training in Rats
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis
Vasopressin-Sensitive Aqp2 Regulation Mediated by the TAZ-NR4A1 Axis in Renal Collecting Duct Cells
Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition
Mitochondrial Calcium Uniporter-Mediated Regulation of the SIRT3/GSK3β/β-Catenin Signaling Pathway in Vascular Remodeling
Therapeutic Potential of GeGen Decoction for the Treatment of Polycystic Ovary Syndrome
Trained Immunity Induced by Oxidized Low-Density Lipoprotein Is Dependent on Glutaminolysis
M2-Like Macrophages Exhibit Sialic Acid-Enhanced Efferocytosis via the Siglec CD22
Homocysteine: Canary in the Coal Mine or Hidden Threat? A Biochemical Study on the Role of Plasma Thiols
Microgravity-Induced Cognitive Decline: Investigating the Pathogenic Mechanisms of RyR2 Hyperphosphorylation and S107 Intervention
Obesity Affects IVF Outcomes and Mevalonic Acid Rescues the Side Effects of Statins on Follicle Growth
MRGPRX2 Mediates Mast Cell-Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine/HRH1/TRPV1 Signaling Pathway
SRSF5 Regulates Trophoblast Apoptosis by Inhibiting NR2F2 Transcriptional Activity Through MLX Ubiquitin Degradation Mediated by Alternative Splicing in Preeclampsia
Akkermansia muciniphila-Derived Outer Membrane Vesicles as a Novel Therapeutic Approach for Mastitis: Insights From In Vitro and Vivo Studies
ATF7–PINK1 Axis Governs Mitophagy and Intestinal Inflammation in Ulcerative Colitis
TLR7/8 Agonist R848 Regulates X Sperm Energy Metabolism in Dairy Cows via Inhibiting Glycolysis and Fatty Acid β-Oxidation by LKB1/AMPK Pathway
Genetic and Functional Dissection of the NFKB2 Gene: Implications for Milk Fatty Acid Biosynthesis in Dairy Cattle
Cellular Landscape of Synovial Chondromatosis Synovium Revealed by Single-Cell RNA Sequencing
Genome-Wide CRISPR-Cas9 Knockout Screening Identifies Genes Modulating Cisplatin-Induced Cytotoxicity in Renal Proximal Tubule Epithelial Cells
MS275 Inhibits Neuroblastoma Cell Growth by Mediating H3K27ac/PROX1 Axis In Silico and In Vitro
The Regulatory Mechanisms of Treponema pallidum Enolase on Macrophages: From Enzymatic Activity to Signal Transduction
NTPDase8 Protects Against Liver Ischemia–Reperfusion Injury in Mice
Exosomal Gene Biomarkers in Osteosarcoma: Mifepristone as a Targeted Therapeutic Revealed by Multi-Omics Analysis
AlkB Homolog 5 Regulates Hexokinase 2-Mediated Glycolysis and Participates in the Progression of Endometriosis
Single-Cell RNA Sequencing Highlights a Contribution of Human Amniotic Mesenchymal Stem Cells-Derived Exosomes to Androgenetic Alopecia
MiR-30d-5p Regulates Bone Remodeling and Vessel Remodeling in Osteoporosis by Targeting GRP78
Integration of Pharmacodynamics, Proteomics, and Metabolomics to Elucidate Effect and Mechanism of Rehmanniae Radix in the Treatment of T2DM
Comparing Soy and Milk Protein Regulation of Hepatic Omega-3 Fatty Acid Biosynthesis
Non-Invasive Ultrasound Treatment Enhances the Release of Skeletal Muscle-Derived Extracellular Vesicles in Mice
Antiproliferative and Apoptotic Effects of Mono/Combined Treatment of Abemaciclib and Regulation of Neuroblastoma-Related miRNAs
Cholesterol Within Phosphatidylcholine Liposomes Attenuates the Expression of Cytokines
Wnt Activation in Mature Dermal Adipocytes Leads to Lipodystrophy and Skin Fibrosis via ATGL-Dependent Lipolysis
Non-Surgical Periodontal Therapy and Metformin Improve Bone Loss in Obese Mice With Periodontitis by Modulating the Gut Microbiota
Therapeutic Effects of Mesenchymal Stem Cell Secretome Derived From Adipose Tissue, Umbilical Cord, and Bone Marrow Against Extended-Spectrum Beta-Lactamase-Producing and Non-Producing Escherichia coli Strains Isolated From Urinary Tract Infections
Lycium barbarum Polysaccharide Ameliorates Hindlimb Unloading-Induced Bone Loss by Targeting Noggin
Multi-Omics Integration Reveals Gut Microbiota-Bile Acid Crosstalk Underlying Baizhu Shaoyao Decoction's Therapeutic Efficacy in Weaning Stress of Piglets
Quercetin and Kaempferol Mitigate Endotoxin-Induced Skeletal Muscle Wasting by Inhibiting KLF15 Expression and Restoring the Antioxidant System
Comparison of Two MPTP Doses on Mouse Behaviors and Pathologies
Dietary Manganese Modulates Microbiota and Intestinal N-Acylethanolamines in a Sex-Specific Manner in Mice With Diet-Induced Obesity
RESEARCH LETTER
Effect of Renal Denervation on Early and Late Stages of Diabetic Nephropathy