Agenda: Protein Arginine Methylation


Conference Organizers:

Rong Huang, PhD, Professor of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN

Jian Xu, PhD, Associate Professor of Dentistry, University of Southern California, Los Angeles, CA

Schedule is subject to change. Each speaker will present their talk live. The presentations' recordings will be accessible to registered attendees after the sessions, contingent upon speakers who have granted permission..

Day 1 Agenda: Biology

Time (Eastern)Event

11:00 am—11:10 am

FASEB Welcome & Organizer Welcome

Session 1Moderator: Frankie Yang, City of Hope, Los Angeles, CA
11:10 am—11:40 am

Keynote Lecture
Identifying a New Effector Protein for SDMA Marks on GAR Motifs

Mark Bedford, PhD, Professor, University of Texas MD Anderson Cancer Center, Houston, TX

11:40 am—12:00 pm

Epigenetic PRMT7 Regulation Promotes Extravasation of Monocytes
Thomas M. Conlon, Team Leader Research Group Immunopathology of COPD, LHI, Institute of Lung Health and Immunity, Munich, Germany

12:00 pm—12:20 pm

The Arginine Methyltransferase PRMT5, a Regulator of the Activity of Steroid Receptor in Breast Cancer
Coralie Poulard, Centre de Recherche en Cancérologie de Lyon, Lyon, France

12:20 pm—12:40 pm

Protein Arginine Methylation in Cancer Cell Signaling
Wenjian Gan, PhD, Associate Professor, Medical University of South Carolina, Charleston, SC

12:40 pm—1:10 pm

Keynote Lecture
Mechanisms of PRMT5-dependent Gene Expression Regulation
David Shechter, PhD, Professor, Albert Einstein College of Medicine, Bronx, NY

1:10 pm—1:25 pm
Session 2Moderator: Pengda Liu, University of North Carolina, Chapel Hill, NC
1:25 pm—1:55 pm

Keynote Lecture
The Dedicated Function of PRMT9 in RNA Splicing
Yanzhong Yang, PhD, Associate Professor, Department of Cancer Genetics and Epigenetics, City of Hope

1:55 pm—2:15 pm

CARM1-mediated Skeletal Muscle Plasticity
Vladimir Ljubicic, PhD, Associate Professor, McMaster University, Hamilton, Canada

2:15 pm—2:35 pm

A New Function of PRMT5 in the Mitochondria
Shihuan Kuang, PhD, Professor of animal sciences, Purdue University, West Lafayette, IN

2:35 pm—2:50 pm

PRMT1-regulated Intron Retention Controls ECM Expression During Craniofacial Development
Julia Lima, MS, Research Assistant, University of Southern California, Los Angeles, CA

2:50 pm—3:20 pm

Keynote Lecture
CARM1 Is a Therapeutic Vulnerability in Breast Cancer
Wei Xu, Marian A. Messerschmidt Professor of Oncology, University of Wisconsin-Madison, Madison, WI

 Day 2: Therapeutics

Time (Eastern)Event
11:00 am—11:10 am
Organizer Recap Day 1 & Kickoff Day 2
Session 1Moderator: N.I. (Nathaniel) Martin, Institute of Biology Leiden (IBL), Leiden University, Leiden, The Netherlands
11:10 am—11:40 am

Keynote Lecture
The Long and Winding Road: Discovering and Validating Protein Arginine Methyltransferase Inhibitors

Gianluca Sbardella, PhD, Professor of Medicinal Chemistry, Università di Salerno, Baronissi, Italy

11:40 am—12:00 pm

Regulation of PRMT1 Activity by Oligomerization
Joan Hevel, PhD, Associate Professor in Biochemistry, Utah State University, Salt Lake City, UT

12:00 pm—12:20 pm

AntiDOTes for Diseases: Chemistry and Biology Match Together to Tackle Epigenetics
Paola Barbara Arimondo, PhD, Institut Pasteur, Paris, France

12:20 pm—12:50 pm

Keynote Lecture
Targeting the Arginine Methylation Binder SMNDC1

Stefan Kubicek, Professor, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

12:50 pm—1:05 pm
Session 2Moderator: Minkui Luo, Memorial Sloan Kettering Cancer Center, New York, NY
1:05 pm—1:25 pm

Chemical Probe to Investigate PRMT9 Function in Myeloid Cells
Dalia Barsyte-Lovejoy, MSc, PhD, Assistant Professor, University of Toronto, Toronto, Canada

1:25 pm—1:45 pm

Mechanism and Impact of PRMT1-PRMT6 Interaction
George Zheng, PhD, Panoz Professor of Pharmacy, University of Georgia, Athens, GA

1:45 pm—2:05 pm

Venturing into the Discovery of New Potential PRMT Inhibitors
Akshay Kulkarni, PhD, Postdoctoral Scholar, Purdue University, West Lafayette, IN

2:05 pm—2:35 pm

Keynote Lecture
Discovery of MTA Cooperative PRMT5 Inhibitor

Ho-man Chan, PhD, Head of Epigenetics, Research & Development, AstraZeneca

2:35 pm—2:40 pm
Organizers' Closing Remarks