Agenda: Liquid-Liquid Phase Separation


Conference Organizer:
Fabrizio Chiti, PhD
Professor of Biochemistry
University of Florence, Florence, Italy

Schedule subject to change. Each speaker will present their talk live, and the entire conference will be recorded.

Time (Eastern)Event

9:00 am – 9:10 am

FASEB Welcome & Organizer Welcome

9:10 am – 9:40 am

Molecular neuropathology and phenotypic heterogeneity of TDP-43 proteinopathies
Manuela Neumann, University of Tübingen, Tübingen, Germany

9:40 am – 10:10 am

Structures of Pathological TDP-43 Filaments in Human Neurodegenerative Diseases
Diana Arseni, Medical Research Country, Cambridge, UK

10:10 am – 10:40 am

Small Molecules that Disassemble Pathogenic Amyloid Fibrils
David Eisenberg, University of California Los Angeles (UCLA), Los Angeles, CA

10:40 am – 11:00 am

Decoding LLPS: Insights into the Role of Charge Pattern in Protein Phase Separation
Greta Bianchi, University of Milan, Bicocca, Italy

11:00 am – 11:20 am


11:20 pm – 11:50 pm

Phase Separation of Full-Length TDP-43 and its Fragments
Fabrizio Chiti, University of Florence, Florence, Italy

11:50 pm – 12:20 pm

Kapb2 Mitigates Aberrant Phase Transition and Neuronal Toxicity in C9orf72-ALS/FTD
Lin Guo, Thomas Jefferson University, Philadelphia, PA

12:20 pm – 12:50 pm

TDP-43, Anisosomes, Aggregation and Neurodegeneration
Don Cleveland, University of California San Diego (UCSD), San Diego, CA

12:50 pm – 1:10 pm

TDP-43 Propagation in iPSCs-derived Cerebral Organoids
Yoshitaka Tamaki, Japan

1:10 pm – 1:40 pm
Virtual Roundtable Discussion and Organizer’s Closing Remarks