Please note that the agenda is subject to change. All talks will be pre-recorded with live question/answer periods, unless noted otherwise. 

The conference is taking place using the British Summer Time zone (BST)FOR EXAMPLE, AS A REFERENCE, PLEASE NOTE THAT 14:00 BST IS 9:00 AM EST.

Day 1: Tuesday, July 20, 2021

 Time – British  

 Summer Time (BST)

 Event - VIRTUAL 
 14:00 – 14:10
 (09:00 AM EST)
 Conference Opens - Welcome Day I
 Opening remarks by Conference Chair: Gareth Inman
 (CRUK Beatson Institute, UK)
 14:10 – 16:10 Session I: Signaling Mechanisms During Development and Disease
 Chair: Cathy Savage-Dunn (Conference Co-Chair)
 (City University of New York, USA)
 14:10 – 14:30 Caroline Hill (Francis Crick Institute, UK)
Self-organising pattern formation in endoderm specification in zebrafish
 14:30 – 14:50 Mary Mullins (University of Pennsylvania, USA)
BMPs in development
 14:50 – 15:00 Short talk 1
Mohammed Farhan Lakdawla (Texas Woman's University, USA)
Characterizing the interactions of the DBL-1/BMP signaling pathway with
 BLMP-1/BLIMP1 transcription regulator in Caenorhabditis elegans
 15:00 – 15:15  Live Q&A Panel Discussion
 15:15 – 15:35 Aryeh Warmflash (Rice University, USA)
Studying self-organized pattern formation with human embryonic stem cells
 15:35 – 15:45 Short talk 2
  Lalage Wakefield (NIH, Bethesda, USA)
 A new TGF-β pathway reporter mouse for analysis of TGF-β signaling in normal homeostasis and
 15:45 – 15:55 Short talk 3
Gregory Gipson (University of Cincinnati, USA)
Exploring the unique biochemistry of an artificial BMP heterodimer
 15:55 – 16:10 Live Q&A Panel Discussion
 16:10 – 16:30 Break
 16:30 – 17:05 Keynote I: TGF-β receptor signaling in epithelial-mesenchymal plasticity of cancer cells
 Peter ten-Dijke (Universiteit Leiden, The Netherlands)
Chair: Tom Thompson (University of Cincinnati, USA)
 17:05 – 17:20 Live Q&A Panel Discussion
 17:20 – 18:20 Poster Session I
 18:20 – 20:20 Session II: Signaling in Cancer
 Chair: Gareth Inman

 (CRUK Beatson Institute, UK)
 18:20 – 18:40 Yibin Kang (Princeton University, USA)
Signaling in Metastasis
 18:40 – 19:00 Sabine Werner (ETH, Zurich, Switzerland)
 A key regulator of wound healing, scar formation and tumorigenesis
 19:00 – 19:10 Short talk 4
 Yi He (McGill University, Canada)
 The CDC42/Rac1 regulator CdGAP is a molecular target of the TGFβ/Smad signaling pathway   and promotes HER2-positive breast cancer growth and metastatis
 19:10 – 19:25 Live Q&A Panel Discussion
 19:25 – 19:45 Ming Li (MSKCC, USA)
 Modulation of the immune microenvironment
 19:45 – 19:55 Short talk 5
Yae Ohata (Uppsala University, Sweden)
TGFβ differentiates pro-stemness from pro-invasive phenotypes
 during cancer cell EMT
 19:55 – 20:05 Short talk 6
 Derek Brazil (Queens University, Belfast, UK)
Mechanisms of GREM1 signaling in intestinal epithelial cells
 20:05 – 20:20 Live Q&A Panel Discussion
 20:20 – 21:20 Meet the Experts
Roselyne Castonguay
Petra Knaus
Aris Moustakas
Michael O'Connor
John Lees-Shepard
Lalage Wakefield
Moderated by the Organizers: Gareth Inman; Cathy Savage-Dunn; Tom Thompson
 21:20 – 21:30 Conclusion of Day I
 Wednesday, July 21, 2021
Day II
 Time – British Summer   Time (BST) Event - VIRTUAL FASEB
 14:00 – 14:05
 (09:00 AM EST)
 Conference Opens - Welcome Day II
 Opening Remarks by Conference Co-Chair: Tom Thompson
 14:05 – 16:05 Session III: Ageing, Metabolism and Repair
 Chair: Tom Thompson
 14:05 – 14:25 Richard T. Lee (Harvard University, USA)
 Update on the controversy on GDF11 and aging
 14:25 – 14:45 Lee Rubin (Harvard University, USA)
Reversing the effects of aging on the brain: a new approach using recombinant GDF11
 14:45 – 14:55 Short talk 7
Masato Morikawa (University of Tokyo, Japan)
Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass     in mice
 14:55 – 15:10 Live Q&A Panel Discussion
 15:10 – 15:30 Aris Economides (Regeneron, USA)
Why ACVR1 antibodies should not be considered as a disease-modifying therapy in FOP
 15:30 – 15:40 Short talk 8
Christina Stuelten (NIH, NCI, USA)
Smurf2 loss leads to reduced skin scaring and increased scar stability
 15:40 – 15:50 Short talk 9
 Mengistu Gebere (University of South Carolina, USA)
Reduction in SMAD3 signaling was more potent than TGFβ1 ligand abatement
 to inhibit age related vascular calcification in Klotho deficient mice
 15:50 – 16:05 Live Q&A Panel Discussion
 16:05 – 17:05 Poster Session II
 17:05 – 18:00 Career Workshop: Career Pathways for Signaling Scientists
 Panelists: Caroline Hill; Aris Economides; Cathy Savage-Dunn; Tom Thompson; Gareth Inman; Alexia-Ileana Zaromytidou
 18:00 – 18:40 Keynote II: Signaling in Stem Cells
 Elaine Fuchs (The Rockefeller University, USA)
 Chair: Cathy Savage-Dunn (City University of New York, USA)
 18:40 – 18:55 Live Q&A Panel Discussion
 18:55 - 19:00 Break
 19:00 – 21:00 Session IV:  Signal Modulation and Therapeutic Strategies
 Chair: Petra Knaus (Freie Universität, Berlin, Germany)
 19:00 – 19:20 Ravi Kumar (Acceleron, USA)
Targeting the TGF-β superfamily therapeutically with ligand traps versus anti-ligand antibodies:
 balancing efficacy and safety
 19:20 – 19:40 Sophie Lucas (Université Catholique de Louvain, Belgium)
Selective inhibition of TGF-b1 produced by GARP-expressing Tregs for the immunotherapy of
 19:40 – 19:50 Short talk 10
 Gonzalo Sanchez-Duffhues (Leiden University, The Netherlands)
Cripto favors chondrocyte hypertrophy via TGF-beta SMAD1/5
 signaling in experimental Osteoarthritis
 19:50 – 20:05 Live Q&A Panel Discussion
 20:05 – 20:25 Rosemary Akhurst (UCSF, USA) Targeting
TGFB signaling in cancer
 20:25 – 20:35 Short talk 11
 Stephen White
(University of Pittsburgh, USA)
Investigations into the function of the parasitic TGF-β mimic TGM6
 20:35 – 20:45 Short talk 12
 Emilie Brule (McGill University, Canada)
Discovery and characterization of a novel inhibin B co-receptor
 20:45 – 21:00 Live Q&A Panel Discussion
 21:00 – 21:10 Awards Ceremony – Best Poster and Best Short Talk
 Cathy Savage-Dunn and Tom Thompson
 21:10 – 21:20 Closing Remarks from Conference Chair Gareth Inman
 End of Conference