The Steroid Hormones and Receptors in Health and Disease Conference - Jointly held with the International Committee on Rapid Responses to Steroid Hormones (RRSH)



***Please note that the times presented are in Central Time (CT).

Day 1: Tuesday, May 25, 2021


Time ***Central Time (CT)Event
8:45 am – 9:00 amWelcome and Introductions:
Dan Frigo (University of Texas MD Anderson Cancer Center) & Eric Prossnitz (University of New Mexico)
9:00 am – 9:30 amKeynote Address: Donald McDonnell (Duke University School of Medicine)
“If We Knew Then What We Know Now, What We Would Have Done Differently to Exploit Nuclear Receptors as Drug Targets”
9:30 am – 9:45 amDiscussion
9:45 am – 12:00 pmNuclear Steroid Receptor Regulation of Macrometabolism
Discussion Leaders: Gian Paolo Rossi (University of Padova) & Sayeepriyadarshini Anakk (University of Illinois)
9:45 am – 10:00 amAdriana Maggi (University of Milan)  
“Liver Estrogen Receptors and Metabolic Function”
10:00 am – 10:15 amCarolyn Cummins (University of Toronto)
Glucocorticoid-induced obesity is mitigated by LXRβ in mice
10:15 am – 10:30 amAndrea Hevener (UCLA)
“Estrogen Regulation of Insulin Actions”
10:30 am – 10:45 amJoint Discussion
10:45 am – 11:00 amBreak
11:00 am – 11:15 amSheng Wu (Johns Hopkins University)
“Nuclear and Extranuclear Hepatic Androgen Receptor Action in Insulin Resistance in Females”
11:15 am – 11:30 amBrian Feldman (UCSF)
“The glucocorticoid receptor links food consumption to adipocyte stem cell activity”
11:30 am – 11:45 amWen Xie (University of Pittsburgh)
“Sex and Tissue-specific Roles of Estrogen Sulfotransferase and Steroid Sulfatase in Energy Metabolism”
11:45 am – 12:00 pmWarren Thomas (Royal College of Surgeons in Ireland)
“Aldosterone regulation of renal Na+ reabsorption via novel protein kinase D isoforms”
12:00 pm – 12:15 pmJoint Discussion
12:15 pm – 1:00 pmBreak
12:15 pm – 1:00 pm
ROUNDTABLE DISCUSSION (to take place on the virtual platform): Science Policy Fellowships – learn about FASEB and FASEB member society-sponsored fellowship opportunities for students and postdocs interested in pursuing a career in science policy. Will include discussion about upcoming openings for U.S. citizens as well as non-citizens, skills that are transferable, and tips for applicants. HOST: Yvette Seger, PhD, FASEB Director of Science Policy
1:00 pm – 3:15 pmClinical Aspects of Therapies Targeting Steroid Hormone Receptors
Discussion Leaders: Jay Gertz (Huntsman Cancer Institute/University of Utah School of Medicine) & Martin Wehling (University of Heidelberg)
1:00 pm – 1:15 pmIris Jaffe (Tufts University)
“Vascular MR: Evolutionary Mediator of Wound Healing Turned Harmful by Our Modern Lifestyle”
1:15 pm – 1:30 pmJames Pru (University of Wyoming)
PGRMC1 and PGRMC2 Functions in Uterine Physiology and Disease”
1:30 pm – 1:45 pmPaul Davis (Albany Medical College, NanoPharmaceuticals LLC)
“Targeting non-genomic thyroid signaling for the treatment of glioblastoma”
1:45 pm – 2:00 pmJoint Discussion
2:00 pm – 2:15 pmBreak
2:15 pm – 2:30 pmWilbert Zwart (Netherlands Cancer Institute)
“Cistromics in Clinical Trials: From Markers to Mechanisms”
2:30 pm – 2:45 pmMathieu Lupien (University of Toronto)
“Epigenetics of Hormone-dependent Cancer”
2:45 pm – 3:00 pmLightning round of selected 3-minute poster abstracts:

Florian Le Billan (University of Toronto) 
"The nuclear receptor coregulator ARGLU1 potentiates glucocorticoid-induced insulin resistance and type 2 diabetes" 

Alicia Arredondo Eve (University of Illinois at Urbana-Champaign)
"Identification of diagnostic plasma biomarkers of coronary microvascular disease in postmenopausal women using machine learning methods"

Ximena Calle Chalco (Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences, University of Chile)
"17-β estradiol regulates MUL1 and cardiomyocyte hypertrophy"

Innocence Harvey (Pennington Biomedical Research Center (LSU))
"Artemisia scoparia Attenuates Glucocorticoid-Induced Lipolysis"

Jia Xu Li (University of Toronto) 
"Disruption of Adipose Tissue Metabolism by Glucocorticoids is Attenuated with LXRβ Antagonism" 
3:00 pm – 3:15 pmJoint Discussion
3:15 pm – 3:30 pmBreak
3:45 pm – 5:00 pmPoster Session


Day 2: Thursday, May 27, 2021


Time ***Central Time (CT)Event
9:30 am – 9:45 amDay Three: Welcome
9:45 am – 12:00 pmNovel Functions of Steroid Receptors in Cancer
Discussion Leaders: Christy Hagan (University of Kansas Medical Center) & Stephen Hammes (University of Rochester Medical Center)
9:45 am – 10:00 amRosamaria Lappano (University of Calabria)
"New findings on the action of GPER in breast cancer”
10:00 am – 10:15 amCarol Lange (University of Minnesota)
“PR and GR - functionally redundant signaling properties in stemness”
10:15 am – 10:30 amLightning round of selected 3-minute poster abstracts

Anasuya Das Gupta (University of Illinois, Urbana Champaign)
"Mechanisms by which 27-Hydroxycholesterol modulates Extracellular Vesicle biogenesis"

Sarah El Kharraz (KU Leuven, Molecular and Cellular Medicine)
"Dimerization of the ligand-binding domain is crucial for normal functioning of the androgen receptor in mice"

Asmaa El-Kenawi (Moffitt Cancer Center)
"Tumor - macrophage metabolic interactions regulate androgen biosynthesis to induce therapeutic resistance in prostate cancer"

Wanting Han (University of Massachusetts Boston)
"CDK4/6 inhibitor enhances the tumor-suppressive activity of high-dose androgen in castration-resistant prostate cancer"

Thu Truong (University of Minnesota)
"PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER+ breast cancer"
10:30 am – 10:45 amJoint Discussion
10:45 am – 11:00 amBreak
11:00 am – 11:15 amMarina Holz (New York Medical College)
“Crosstalk between mTOR and estrogen signaling”
11:15 am – 11:30 amMatt Sikora (University of Colorado, School of Medicine)
“Unique Estrogen Receptor Biology Underlies Therapy Response and Resistance in Lobular Carcinoma”
11:30 am – 11:45 pmScott Tomlins (Strata Oncology)
“High-throughput "Omics" to Identify Driver Mutations and Gene Fusions in Cancer”
11:45 pm – 12:00 pmJoint Discussion
12:00 pm – 1:00 pmBreak
1:00 pm – 2:45 pmTargeting Steroid Receptors: New Mechanisms
Discussion Leaders: Donald DeFranco (University of Pittsburgh) & Ellis Levin (University of California- Irvine)
1:00 pm – 1:15 pmElahe Mostaghel (Fred Hutchinson Cancer Center)
 “Adrenal androgens and AR axis inhibition in prostate cancer – mechanism of resistance and predictors of response”
1:15 pm – 1:30 pmDouglas Kojetin (Scripps Research-Florida)
“Ligand-induced PPARγ repression made crystal clear with NMR spectroscopy”
1:30 pm – 1:45 pmJoint Discussion
1:45 pm – 2:00 pmBreak
2:00 pm – 2:15 pmEdward Filardo (University of Iowa)
“Dual specificity PROTACs that target plasma membrane and intracellular estrogen receptors”
2:15 pm – 2:30 pmJohn Katzenellenbogen (University of Illinois)
“Unusual Effects of Estrogens Through Estrogen Receptor Beta and From Very Low Affinity Ligands”
2:30 pm – 2:45 pmJoint Discussion
2:45 pm – 3:00 pmBreak
3:00 pm – 4:45 pmNuclear Steroid Receptor/Metabolic Crosstalk
 Discussion Leaders: 
Kristy Brown (Weill Cornell Medicine) & Subhamoy Dasgupta (Roswell Park Comprehensive Cancer Center)
3:00 pm – 3:15 pmIan Mills (Queens University Belfast)
“AR-regulated Metabolism in Prostate Cancer”
3:15 pm – 3:30 pmRebecca Riggins (Georgetown University)
“ERR Metabolism in Breast Cancer, Metabolism in GBM”
3:30 pm – 3:45 pmJoint Discussion
3:45 pm – 4:00 pmBreak
4:00 pm – 4:15 pmGiorgia Zadra (Institute of Molecular Genetics, National Research Council-Italy)
“Modulation of intra-tumor lipid metabolism is a non-canonical approach to target AR receptor"
4:15 pm – 4:30 pmErik Nelson (University of Illinois)
“Cholesterol, ER and LXRs Functions in the Breast Cancer Metastatic Tumor Microenvironment”
4:30 pm – 4:45 pmPhil Shaul (UTSW)
“Estrogen Receptor Signaling in Endothelium in Cardiometabolic Health and Disease”
4:45 pm – 5:00 pmJoint Discussion
5:00 pm – 5:15 pmWrap-up by Conference Organizers