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Review Series in The FASEB Journal Provides Insight into Alzheimer’s Disease

Tuesday, September 24, 2019
The FASEB Journal published a series of reviews covering the processes that appear to be involved in the pathogenesis of neurodegenerative disorders, particularly Alzheimer’s disease. These essays have appeared at regular intervals in The FASEB Journal over the past two years.

The series' editor Joel N. Buxbaum, MD, invited authors who were working on aspects of Alzheimer's disease outside of the standard amyloid-beta (Aß) hypothesis of its pathogenesis.

“There have been many reviews both supporting and questioning the etiologic role of Aß in the late-onset, sporadic form of Alzheimer’s disease,” Buxbaum wrote in a closing perspective published in August 2019. “Reciting either of those scientific positions would be redundant.”

“I believe that these contributions have significantly informed readers’ awareness of the current state of knowledge of Alzheimer’s disease,” Buxbaum said. “While a silver therapeutic bullet does not seem to be in the offing, we continue to gain insight into the mechanisms responsible for synaptic loss and the consequent functional deterioration.”

“When Dr. Buxbuam launched this series, I knew it would be a success, but it has exceeded both of our expectations,” said Thoru Pederson, PhD, Editor-in-Chief of The FASEB Journal. In addition, as Dr. Pederson expressed in his August editorial, the closing perspective by Dr. Buxbaum was not just a summary of the series but itself "a masterpiece" on the subject.