The Mobile DNA Conference: Evolution, Diversity, and Impact

Agenda

The Mobile DNA Conference: Evolution, Diversity, and Impact

All talks will be either pre-recorded or presented live, with live question/answer periods following each session. All events are taking place in Eastern Daylight Time. The agenda is subject to change.

Day 1: Tuesday, June 8, 2021

Time Event 
08:15 am – 08:30 amConference Opens - Welcome Day I
 Conference Chair: Victoria Belancio
 Co-Organizers: David A. Largaespada; Molly Gale Hammell; Josefa Gonzalez; Steven N. Austad
08:30 am – 09:20 amKeynote Lecture: Zsuzsanna Izsvak
Titled: A junk to treasure?
09:20 am – 09:30 amLive Q&A with the Keynote
09:30 am – 11:30 amSession I: Tools and Resources for Studies Involving TEs
 Session Chair: Gael Cristofari
09:30 am – 09:55 am Paul Flicek
“Resources, their use, and what’s new?”
09:55 am – 10:20 amJef Boeke
An unexpected function for an Alu sequence
10:20 am – 10:30 amLive Q&A Panel Discussion
10:30 am - 10:55 amAlice Lee
Detection of de novo TE inserts – progress and technical barriers
10:55 am – 11:20 amPrescott Deininger
Detection of TE mRNA expression – short versus long reads, single cell approaches, malignant versus normal cells
11:20 am – 11:30 amLive Q&A Panel Discussion
11:30 am - 11:40 amShort Talk 1
Jessica Storer
Curation guidelines for de novo generated transposable element families
11:40 am – 11:50 amShort Talk 2
Raquel Garza
Expression of LINE-1 elements in the developing and mature human brain at single-cell type resolution
11:50 am - 12:00 pmShort Talk 3
Wilson McKerrow
LINE-1 Retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5'-single cell RNA-Seq
12:00 pm – 12:15 pmLive Q&A Panel Discussion
12:15 pm – 12:30 pmBreak
12:30 pm – 2:00 pmPoster Session I
2:00 pm – 3:30 pmSession II:  TE Evolution and Diversity
 Session Chair: Josefa Gonzalez
2:00 pm – 2:25 pmSusan Wessler
Deciphering the strategies evolved by a very successful transposable element
2:25 pm – 2:50 pmCristina Vieira
Transposable elements in Drosophila suzukii invasive species
2:50 pm – 3:15 pmDavid Ray
TE diversity in mammalian genomes
3:15 pm – 3:30 pmLive Q&A Panel Discussion
3:30 pm – 3:40 pmShort Talk 4
Thomas Carter
Mosaic cis-regulatory evolution drives human endogenous retrovirus HERV-H transcriptional partitioning
3:40 pm – 3:50 pmShort Talk 5
Jennifer Frost
Functional evaluation of transposable elements as enhancers in human trophoblast
3:50 pm - 4:00 pmShort Talk 6
Rachel Cosby
Investigating the role of the host-transposase fusion gene THAP7 in vertebrate neurodevelopment and human intellectual disability
4:00 pm – 4:15 pmLive Q&A Panel Discussion
4:15 pm – 4:30 pmBreak
4:30 pm – 5:30 pmSocial Hour/history of the TE field – a Discussion that will Reflect on the Discovery of TEs and Tools
Social Hour Moderator: Victoria Belancio
Leaders: Haig Kazazian, Perry Hackett, Zsuzsanna Izsvak, Susan Wessler, John Moran, Prescott Deininger, Dixie Mager, Zoltan Ivics and Nancy Craig
5:30 pm - 5:45 pmConclusion - End of Day I

 

Day 2: Wednesday, June 9, 2021

TimeEvent
08:15 am – 08:30 amConference Opens - Welcome Day II
 Conference Chair: Victoria Belancio
08:30 am – 10:30 amSession III: Mechanisms of TE Mobilization - Its Impact on Disease and Treatment
 Session Chair: Molly Gale Hammell
08:30 am – 08:55 am John Moran
Studies of a human retrotransposon
08:55 am – 09:20 amKathleen Burns
TE mobilization in cancers – contribution to transformation and progression
09:20 am – 09:30 amLive Q&A Panel Discussion
09:30 am - 09:55 amDavid Largaespada
TEs as gene discovery tools - somatic cell, cell line, germline tools in vertebrates
09:55 am – 10:20 amDrew Deniger
Development of Sleeping Beauty transposed TCR-T cells for adoptive cell therapy of cancer
10:20 am – 10:30 amLive Q&A Panel Discussion
10:30 am - 10:45 amBreak
10:45 am – 10:55 amShort Talk 7
Luz Jubierre Zapater
PGBD5 DNA transposase induces DNA damage in the brain and is required for its correct development
10:55 am – 11:05 amShort Talk 8
Gerald Schumann 
Cytoplasmic synthesis of endogenous Alu complementary DNA by LINE-1 mediated reverse transcription is a cause for age-related macular degeneration (AMD)
11:05 am – 11:15 amShort Talk 9
Kasia Siudeja
Unraveling the features of somatic transposition in the Drosophila intestine
11:15 am – 11:25 amShort Talk 10
Katsumi Yamaguchi
Striking heterogeneity of somatic L1 retrotransposition in single normal and cancerous gastrointestinal cells
11:25 am – 11:45 amLive Q&A Panel Discussion
11:45 am – 12:00 pmBreak
12:00 pm – 1:00 pmCareer Development Session
Moderator: Victoria Belancio
Speakers: Amy Lossie, Program Director - Genetics, Epigenetics and Developmental Neuroscience Branch, NIDA
Ian Fingerman, Program Director - DNA and Chromosome Aberrations Branch, Division of Cancer Biology, NCI
Career Development presentation and discussion for students, postdocs and juniors PIs, but all conference participants are encouraged to attend.
1:00 pm – 1:15 pmBreak
1:15 pm – 2:30 pmSession IV: TEs, Genetics, and Epigenetics
 Session Chair: Rita Rebollo
1:15 pm – 1:40 pmRob Martienssen
LTR retrotransposons, epigenetics, and small RNAs
1:40 pm – 1:50 pmShort Talk 11
Kenji Ichiyanagi
B2 SINE copies serve as a transposable boundary of DNA methylation and histone modifications in the mouse
1:50 pm - 2:00 pmShort Talk 12
Nelson Lau
Transposable element landscape changes are buffered by RNA silencing in aging Drosophila
2:00 pm – 2:10 pmShort Talk 13
Sophie Lanciano
Young human LINE-1 retrotransposons and their target loci are subject to multiple and cell type-specific layers of epigenetic regulation
2:10 pm – 2:30 pmLive Q&A Panel Discussion
2:30 pm – 3:30 pmPoster Session II
3:30 pm – 5:00 pmSession V: Genome Stability and Aging
 Session Chair: Victoria Belancio
3:30 pm – 3:55 pmJudith Campisi
DNA Repair, Cancer, and Aging
3:55 pm – 4:20 pmFelipe Sierra
Geroscience 101
4:20 pm – 4:45 pmSteven Austad
Sex differences in aging and disease in model and non-model organisms
4:45 pm – 5:00 pmLive Q&A Panel Discussion
5:00 pm – 5:15 pmFinal Remarks - Conclusion of Day II 
Conference Chair: Victoria Belancio