Agenda

Agenda

The Microbial Pathogenesis Conference: Mechanisms of Infectious Disease

Please note that all times listed currently reflect US Central Time (CT). The schedule is subject to change.

Presentations are live or pre-recorded followed by live Q&A

Day 1: Tuesday, July 13th, 2021

 
TimeEvent
8:30 am – 8:45 amDay One Welcome and Introductions: 
Kim Orth (UT Southwestern Medical Center) & Ken Campellone (University of Connecticut)
8:45 am – 9:30 amKeynote Address: Andrew Camilli (Tufts University) 
Fields Lecture
The Varied Impact of Phages on Cholera
9:30 am – 9:45 amQuestions and Answers
9:45 am – 12:00 pmSession 1: Pathogens and Disease
Chair: Kim Orth (UT Southwestern Medical Center)
9:45 am – 10:10 amRaphael Valdivia (Duke University)  
Genetics and genomics basis for host colonization and mucin metabolism by the beneficial gut microbe Akkermansia muciniphila
10:10 am – 10:35 amDor Salomon (Tel Aviv University)
Activation of inflammasome-mediated cell death by a Vibrio T6SS
10:35 am – 11:00 amMariana Byndloss (Vanderbilt University)
Microbiota-derived aspartate drives Salmonella expansion during colitis
11:00 am – 11:25 amKat Milligan-Myhre (University of Connecticut)
Host environment, microbiota, and potential pathogen interactions
11:25 am – 11:40 amShort Talk: Katrina Velle (University of Massachusetts, Amherst)            
Actin dynamics drive pathogenic behaviors in a relative of the "brain-eating amoeba"
11:40 am – 11:55 amShort Talk: Krystal Ching (NYU School of Medicine)
Autophagy mediated mechanisms of protection against SARS-CoV-2
11:55 am – 1:15 pmBreak 
12:15 pm – 1:00 pmMeet the Experts Session 1 - Breakout rooms for Keynotes 1&2, Sessions 1,2,3 Speakers
1:15 pm – 3:30 pmSession 2: Structural Biology and Pathogens
 Chair: Ken Campellone (University of Connecticut)
1:15 pm – 1:40 pmVinnie Tagliabracci (UTSW)
Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases
1:40 pm – 2:05 pmMimi Ho (Columbia University)
Structural parasitology of the Malaria Parasite Plasmodium falciparum
2:05 pm – 2:30 pmLeah Cowen (University of Toronto)
Structure-guided Approaches to Develop Antifungals to Cripple Drug-resistant Fungal Pathogens
2:30 pm – 2:55 pmGaya Amarasinghe (Washington University)
Enter, hide, and detect: molecular mechanisms at the host-viral interface
2:55 pm – 3:10 pmShort Talk: Karan Kaval (University of Texas Southwestern Medical Center)
Transertion: Localization, Expression and Assembly of the V. parahaemolyticus T3SS2
3:10 pm – 3:25 pmShort Talk: Erin Green (Vanderbilt University Medical Center)
A bacterial dehydrin promotes pathogen desiccation tolerance
3:25 pm – 3:45 pmBreak
3:45 pm – 5:00 pmPoster Session 1 - Posters will be available online for viewing a few days prior to the virtual SRC; session time will be devoted to Q&A between poster presenters and attendees
5:00 pm – 6:00 pmHappy Hour

 

Day 2: Wednesday, July 14th, 2021

 
TimeEvent
8:30 am – 8:45 amDay Two: Welcome Address and Summary of Day One
8:45 am – 9:30 amKeynote Address: Andrea Carfi (Moderna)
Development of the Moderna COVID-19 Vaccine (mRNA-1273) and Preparing for Variants of Concern
9:30 am – 9:45 amQuestions and Answers
9:45 am – 12:00 pmSession 3: Anti-Microbial Drug Discovery
Chair: Kim Orth (UT Southwestern Medical Center)
9:45 am – 10:10 amAnita Sil (University of California at San Francisco)
Regulation of cell shape and virulence factor expression in response to temperature in the fungal pathogen Histoplasma capsulatum
10:10 am – 10:35 amMichael Lorenz (UTHSC)
A 12 amino acid peptide derived from Enterococcus EntV is an antivirulence agent against Candida albicans
10:35 am – 11:00 amElizabeth Winzeler (University of California at San Diego)
Discovering targets for eukaryotic pathogens: tales from two phyla
11:00 am – 11:25 amSteve Rutherford (Genentech)
Inhibiting BamA to understand outer membrane protein folding
11:25 am – 11:40 amShort Talk: Shelby Priest (Duke University)
Rampant transposition and loss of RNAi cause hypermutation and antifungal drug resistance in Cryptococcus neoformans
11:40 am – 11:55 amShort Talk: Richard Lavin (Tufts University)
Targeting Mycobacterium tuberculosis environmental cue response for the development of antitubercular drugs
11:55 am – 1:15 pmBreak
12:15 pm – 1:00 pmMeet the Expert Session 2 - Breakout rooms for Keynote 3, Sessions 4,5,6 Speakers
1:15 pm – 2:30 pmPoster Session 2 - Posters will be available online for viewing a few days prior to the virtual SRC; session time will be devoted to Q&A between poster presenters and attendees
2:30 pm – 2:45 pmBreak
2:45 pm – 5:00 pmSession 4: Health and Metabolism for Pathogens
 Chair: Ken Campellone (University of Connecticut)
2:45 pm – 3:10 pmHeran Darwin (New York University)
Aldehydes: An Achilles' Heel for Mycobacterium tuberculosis
3:10 pm – 3:35 pmIleana Cristea (Princeton University)
Virus regulation of mitochondrial structure and bioenergetics viewed through the lens of proteomics
3:35 pm – 4:00 pmMichael Fischbach (Stanford University)
Inducing antigen-specific T cells with engineered commensals
4:00 pm – 4:25 pmVernon Carruthers (University of Michigan)
Toxoplasma autophagy and persistence of a pervasive brain parasite
4:25 pm – 4:40 pmShort Talk: Kayla Sylvester (Duke University)
Characterization of the tubovesicular network in Plasmodium vivax liver stage hypnozoites and schizonts
4:40 pm – 4:55 pmShort Talk: Audrey Chong (Laboratory of Bacteriology, Rocky Mountain Labs, NIAID, NIH)
Cytosolic replication in epithelial cells fuels intestinal expansion and chronic fecal shedding of Salmonella Typhimurium

 

Day 3: Thursday, July 15th, 2021

 
TimeEvent
8:30 am – 8:45 amDay Three: Welcome Address and Summary of Day Two
8:45 am – 9:30 amKeynote Address: Dominique Soldati-Favre (University of Geneva)
Metabolic needs and capabilities of Toxoplasma gondii during acute and chronic infection
9:30 am – 9:45 amQuestions and Answers
9:45 am – 12:00 pmSession 5: Host-Pathogen Interactions
Chair: Kim Orth (UT Southwestern Medical Center)
9:45 am – 10:10 amCarolyn Coyne (Duke University)
Antimicrobial signaling at the maternal-fetal interface
10:10 am – 10:35 amShaeri Mukherjee (University of California at San Francisco)
How to make a home in the Endoplasmic Reticulum
10:35 am – 11:00 amNels Elde (University of Utah)
Linking immune responses to virus discovery in zebrafish
11:00 am – 11:25 amHiten Madhani (University of California at San Francisco)
Manipulation of Macrophage Polarization by a Fungal Meningitis Pathogen
11:25 am – 11:40 amShort Talk: Brittney Moore (UW School of Medicine and Public Health)
Comparison of structural brain imaging in infant macaques with prenatal Zika virus exposure in mid- and late-first trimester
11:40 am – 11:55 amShort Talk: Minna Ding  (University of Minnesota)
Defining the criteria for establishing a murine model of latent Cryptococcus neoformans infection using clinical isolates
11:55 am – 1:00 pmBreak
12:00 pm – 12:55 pmCareer Development: Meet Experts with Careers in Science
 Victoria McGovern (Burroughs Wellcome Fund), Steve Rutherford (Genentech), and Patricia Haggerty (NIH/NIAID)
1:15 pm – 3:25 pmSession 6: Drugs and Resistance
 Chair: Ken Campellone (University of Connecticut)
1:15 pm – 1:40 pmAnna Selmecki (University of Minnesota)
High copy number amplifications during adaptation to antifungal drugs
1:40 pm – 2:05 pmAndreas Baumler (University of California at Davis)
Gastrointestinal host-pathogen interaction in the age of microbiome research
2:05 pm – 2:30 pmBreck Duerkop (University of Colorado)
Enterococcal phages and antibiotics dictate polymicrobial interactions
2:30 pm – 2:55 pmDavid Roos (University of Pennsylvania)
Integrative biology in the Omics era
2:55 pm – 3:10 pmShort Talk: Kimberly Davis (Johns Hopkins Bloomberg School of Public Health)
Subpopulations of stressed Y. pseudotuberculosis have reduced antibiotic susceptibility
3:10 pm – 3:25 pmShort Talk: Kyle Gibbs (Duke University)
Natural genetic variation in mucolipin-2 restricts Salmonella Typhi replication inside human leukocytes through magnesium deprivation
3:25 pm – 3:55 pmBusiness Meeting
3:55 pm – 4:10 pmWrap-up by Conference Organizers