All times are listed based on Eastern Time (ET). (Please note: The schedule is subject to change.)

All presentations are mostly pre-recorded and followed by live Q&A.

Day 1: Tuesday, July 13, 2021

TimeTitle/Topic Event
8:30 AM - 8:45 AMWelcome Address: 20th Anniversary of the Lysophospholipid and Related Mediators FASEB SRC
Conference Organizers: Susan Schwab / New York University, USA and Olivier Peyruchaud / INSERM, France 
Conference Co-organizers: 
Satoshi Ishii / Akita University, Japan
Eric Camerer / INSERM, France
8:45 AM – 9:15 AM
Keynote Speaker I
Timothy Hla (Harvard University, USA)
S1P: The well-tempered lysolipid
 Moderators: Susan Schwab and Eric Camerer
9:15 AM – 9:30 AMLive Q&A with the Keynote
9:30 AM - 11:55 AMSession I: Lysophospholipids in cardiovascular biology
Session Chairs: Julie Saba and Christina Christoffersen
9:30 AM – 9:50 AMSusan Smyth (University of Kentucky, USA)
Lysophosphatidic acid signaling in cardiovascular diseases
9:50 AM - 10:10 AMKeisuke Yanagida (National Center for Global Health and Medicine, Japan)
S1P-dependent transcriptional switch between physiological and pathological angiogenesis
10:10 AM – 10:20 AMShort Talk 1
Andrew Kuo (Boston Children's Hospital, USA)
De Novo Sphingolipid Synthesis by Endothelial cells is Critical for Sphingolipid Homeostasis In Circulation and Retinal Angiogenesis
10:20 AM – 10:35 AMLive Q&A
10:35 AM – 10:55 AMAnnarita di Lorenzo (Weill Cornell Medical College, USA)
Endothelial sphingolipid regulation in health and disease
10:55 AM – 11:15 AMR Sathish Srinivasan (Oklahoma Medical Research Foundation, USA)
Role of S1PR1 in shear stress-regulated lymphatic vascular patterning
11:15 AM – 11:25 AMShort Talk 2
Ilaria Del Gaudio (Weill Cornell Medical College/Paris Cardiovascular Research Center)
Endothelial Spns2 regulation of vascular tone and blood pressure via sphingosine-1-phosphate 
11:25 AM – 11:35 AMShort Talk 3
 Lisa Wilsbacher 
(Northwestern University Feinberg School of Medicine, USA)
Deletion of Sphingosine 1-Phosphate Receptor 1 in cardiomyocytes during development leads to abnormal ventricular conduction and fibrosis
11:35 AM – 11:55 PMLive Q&A
11:55 AM - 12:15 PMBreak
   12:15 PM – 1:00 PMCareer Development Session:
Annarita Di Lorenzo; Marianne Martinic; Satoshi Ishii; Olivier Peyruchard
Moderator: Olivier Peyruchard and Satoshi Ishii
1:00 PM – 3:10 PMSession II: Lysophospholipid chaperones and biomarkers
Session Chairs: Annarita di Lorenzo and Kevin Lynch
1:00 PM – 1:20 PMChristina Christoffersen (University of Copenhagen, Denmark)
ApoM/S1P and its impact on triglyceride metabolism
1:20 PM – 1:40 PMMarkus Gräler (University Hospital Jena, Germany)
S1P-driven adaptive mechanisms in Covid-19 patients
1:40 PM – 1:50 PMShort Talk 4
Ali Javaheri (Washington University School of Medicine, USA)
Apolipoprotein M regulates myocardial autophagy and promotes heart failure survival
1:50 PM – 2:05 PMLive Q&A
2:05 PM – 2:25 PMMette Mathiesen Janiurek (University of Copenhagen, Denmark)
APOM/S1M signaling maintains low levels of adsorptive-mediated transcytosis across the blood-brain barrier
2:25 PM – 2:45 PMZhongwei Cao (Icahn School of Medicine at Mount Sinai, USA)
Aging reprograms S1P signaling in the vascular niche to suppress regeneration and promote fibrosis
2:45 PM – 2:55 PMShort Talk 5
Kuniyuki Kano (The University of Tokyo, Japan)
A simple and optimal plasma preparation method for precise quantification of lysophoshatidic acid
2:55 PM – 3:10 PMLive Q&A
3:10 PM – 3:30 PMBreak
3:30 PM - 5:50 PMSession III: Lysophospholipids in immunology and inflammation
Session Chairs: Susan Schwab and Jerold Chun
3:30 PM – 3:50 PMJunken Aoki (University of Tokyo, Japan)
Roles of lysophosphatidylserine signaling in regulating immune responses
3:50 PM – 4:10 PMRaul Torres (University of Colorado, USA)
Lysophosphatidic acid regulation of CD8 T cell antigen receptor signaling and immunity
4:10 PM – 4:20 PMShort Talk 6
Bisera Stepanovska-Tanturovska (University of Bern, Switzerland)
Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.
4:20 PM – 4:35 PMLive Q&A
4:35 PM – 4:55 PMAudrey Baeyens (New York University, USA)
Monocyte-derived S1P in the lymph node regulates immune responses
4:55 PM – 5:15 PMLeyre Brizuela (Claude Bernard University, France)
Sphingosine 1-phosphate signaling, inflammation and spondyloarthritis
5:15 PM – 5:35 PMSzandor Simmons (Charité Universitätsmedizin Berlin, Germany)
High endothelial cell-derived sphingosine-1-phosphate regulates dendritic cell localization and vascular integrity in the lymph node
5:35 PM – 5:45 PMShort Talk 7
 Zelei Yang 
(University of Alberta, Canada)
Enhanced Breast Tumor Infection with Human Cytomegalovirus through Fibroblasts and PDGFRα facilitates Metastasis-Inducing Inflammation
5:45 PM - 6:05 PMLive Q&A
6:05 PM - 6:15 PMConclusion - End of Day I


Day 2: Wednesday, July 14, 2021

TimeTitle/Topic Event
8:30 AM – 8:40 AMWelcome to Day II
Olivier Peyruchaud / INSERM, France 
Satoshi Ishii / Akita University, Japan
8:40 AM – 9:10 AM
Keynote Speaker II
Wouter Moolenaar (The NKI-Netherlands)
Lysophosphatidic acid (LPA): from discovery to anti-tumor immunity
 Moderators: Satoshi Ishii and Olivier Peyruchaud
9:10 AM – 9:25 AMLive Q&A with the Keynote
9:25 AM - 12:10 PMSession IV: Lysophospholipids in cancer
Session Chairs: Sarah Spiegel and Olivier Peyruchaud 
9:25 AM – 9:45 AMViswanathan Natarajan (University of Illinois at Chicago, USA)
Lysocardiolipin acyltransferase regulates lung cancer proliferation and migration by modulating mitochondrial dynamics
9:45 AM - 10:05 AMCéline Colacios (Inserm, Toulouse, France)
Sphingolipid metabolism in cancer immune surveillance
10:05 AM – 10:25 AMAndreas Weigert (Goethe-University, Frankfurt, Germany)
S1PR4 signaling in tumor-associated inflammation
10:25 AM – 10:40 AMLive Q&A
10:40 AM – 11:00 AMGabor Tigyi (University of Tennessee, USA)
The ATX-LPAR5 in the tumor microenvironment
11:00 AM – 11:20 AMKazuhito Naka (Hiroshima University, Japan)
The lysophospholipid metabolism enzyme Gdpd3 maintains chronic myelogenous leukemia stem cells
11:20 AM – 11:40 AMFrancesca Auciello (Fondazione Santa Lucia, Italy)
A stromal autotaxin-LPA signalling axis promotes pancreatic tumor progression
11:40 AM – 11:50 AMShort Talk 8
Pratibha Malhorta (Curtin University, Australia)
Exosomal lysophospholipids play key role in cancer progression
11:50 AM – 12:10 PMLive Q&A
12:10 PM - 12:30 PMBreak
 12:30 PM – 1:30 PMMeet the Experts Session
Julie Saba; Jerold Chun; Richard Proia; Junken Aoki and Gabor Tigyi
 Moderator: Susan Schwab and Eric Camerer
1:30 PM – 4:10 PMSession V: Cell biology and biochemistry of lysophospholipids
Session Chairs: Markus Gräler and Junken Aoki
1:30 PM – 1:50 PMRichard Proia (National Institutes of Health, USA)
The itinerary of sphingosine-1-phosphate uptake
1:50 PM – 2:10 PMKevin Lynch (University of Virginia, USA)
The Pharmacology of S1P Transport Inhibition
2:10 PM – 2:20 PMShort Talk 9
Long Nguyen (National University of Singapore, Singapore)
Mfsd2b and Spns2 coordinate to provide extracellular S1P for development and protection from pathological conditions
2:20 PM – 2:30 PMShort Talk 10
Taiga Iwama (The University of Tokyo, Japan)
Development of an on-tissue derivatization method for MALDI-MS Imaging of LPA and S1P
2:30 PM – 2:50 PMLive Q&A
2:50 PM – 3:10 PMChristopher Westlake (National Institutes of Health, USA)
Lysophosphatidic acid signaling regulates primary cilium assembly initiation
3:10 PM – 3:30 PMElena Pugacheva (West Virginia University School of Medicine, USA)
LPA signaling is regulated through the primary cilium: a novel target in glioblastoma
3:30 PM – 3:50 PMJanis K. Burkhardt (University of Pennsylvania, USA)
Lymphocyte egress signal S1P promotes ERM-guided, bleb-based migration
3:50 PM – 4:00 PMShort Talk 11
Fernando Salgado-Polo (Netherlands Cancer Institute, Netherlands)
The role of the Autotaxin tunnel in LPA delivery and its relevance in liver disease
4:00 PM – 4:20 PMLive Q&A
4:30 PM – 6:00 PMPoster Session I
 Conclusion - End of Day II


Day 3: Thursday, July 15, 2021

TimeTitle/Topic Event
8:30 AM – 8:40 AMWelcome to Day III
Olivier Peyruchaud / INSERM, France 
Satoshi Ishii / Akita University, Japan
8:40 AM - 12:05 PMSession VI: Lysophospholipids: From drug discovery to clinical trials
Session Chairs: Timothy Hla and Susan Smyth
8:40 AM – 9:00 AMSarah Spiegel (Virginia Commonwealth University, USA)
Sphingosine-1-Phosphate: From Bench to Clinic
9:00 AM - 9:20 AMHugh Rosen (Scripps Research Institute, San Diego, USA)
Mechanisms of S1P modulation of viral cytokine release syndrome
9:20 AM – 9:40 AMJulie Saba (UC San Francisco, USA)
Sphingosine phosphate lyase: From yeast gene to gene therapy
9:40 AM – 9:50 AMShort Talk 12
Manisha Ray (Sanford Burnham Prebys Medical Discovery Institute, San Diego, USA)
Physiologically relevant binding affinity measurements of lysophospholipids using a free-solution, label-free interferometric assay
9:50 AM – 10:00 AMShort Talk 13
Shintaro Maeda (Kyoto University, Japan)
Crystal structure of active sphingosine-1-phosphate receptor 3
10:00 AM – 10:25 AMLive Q&A
10:25 AM - 10:45 AMFu-Dong Shi (Beijing Tiantan Hospital, China)
Modulating brain inflammation: compartment, timing and drug selection
10:45 AM – 11:05 AMMarianne Martinic (Idorsia Pharmaceuticals, Switzerland)
Cenerimod, a novel S1P1 receptor modulator, targets the immunopathology of systemic lupus erythematosus and Sjögren’s Syndrome in two preclinical mouse models
11:05 AM – 11:15 AMShort Talk 14
 Fukasawa (Ochanomizu University, Tokyo, Japan)
Biosynthesis of β-lysophosphatidic acid from cyclic phosphatidic acid by autotaxin, and bioactivity of a novel β-lysophosphatidic acid analogue, 2-carba-lysophosphatidic acid
11:15 AM - 11:25 AMShort Talk 15
Deepa Jonnalagadda (Sanford Burnham Prebys Medical Discovery Institute, San Diego, USA)
Sphingosine 1-phosphate (S1P) inhibits astrocytic glutamate uptake through S1P2-Ga12 signaling
11:25 AM - 11:35 AMShort Talk 16
Andreane Cartier (Boston Children's Hospital, USA)
S1P receptor 1 expression in endothelial cells promotes vascular normalization and antitumor therapies
11:35 AM – 12:00 PMLive Q&A
12:00 PM – 12:30 PMBreak
12:30 PM – 1:30 PM

 Meet the Experts
 Sarah Spiegel, Kevin Lynch, Richard Proia, Timothy Hla and Wouter Moolenaar 
 Moderators: Susan Schwab and Eric Camerer

1:30 PM – 2:45 PMPoster Session II
2:45 PM – 5:50 PMSession VII: Novel aspects of lysophospholid biology
Session Chairs: Richard Proia and Zhongwei Cao
2:45 PM – 3:05 PMJerold Chun (Sanford Burnham Prebys Medical Discovery Institute, San Diego, USA)
Lysophospholipid signaling in brain disorders
3:05 PM – 3:25 PMIrma Machuca-Gayet (Inserm, Lyon, France)
ATX role in bone mass regulation 
3:25 PM – 3:45 PMDylan Stavish (University of Sheffield, UK)
Generation and trapping of a mesoderm biased state of human pluripotency
3:45 PM – 3:55 PMShort Talk 17
Candide Alioli (INSERM U1033 Lyos, France)
LPA1 controls FGF2-mediated osteocyte dendrite network
3:55 PM – 4:15 PMLive Q&A
4:15 PM – 4:35 PMKun-Liang Guan (UC San Diego, USA)
Mechanism of the Hippo pathway regulation and its role in cancer
4:35 PM – 4:55 PMDolly Mehta (University of Illinois, USA)
Programming to S1PR1+ Endothelial Cells Promote Restoration of Vascular Integrity
4:55 PM – 5:05 PMShort Talk 18
Yugo Takagi (The University of Tokyo, Japan)
Search for novel oxidized phospholipid receptor involved in pruritic skin disease and its functional analysis
5:05 PM – 5:15 PMShort Talk 19
Long Chung (The Centenary Institute, Australia)
Role of sphingosine 1-phosphate in mitochondrial biology and metabolic disorders in the liver
5:15 PM – 5:25 PMShort Talk 20
Uranbileg Baasanjav (The University of Tokyo, Japan)
Involvement of SPL in the pathogenesis of cancer through converting sphingolipids to glycerophospholipids
5:25 PM - 5:50 PMLive Q&A
5:50 PM – 6:00 PMFinal Remarks and Conclusion - End of Conference