The Growth Hormone (GH)/Prolactin (PRL) Family in Biology & Disease Conference


Day 1: May 18, 2021

Time (Eastern)Event
8:30 am - 8:40 amWelcome and introductions from the conference organizers:
Dave R. Grattan, PhDHead and Professor, Department of Anatomy, University of Otago, Dunedin, New Zealand
Darlene Berryman, PhDAssociate Dean, Research and Innovation and Professor, Biomedical Sciences, Ohio University, Athens, USA
Shoshana Yakar, PhDProfessor, Molecular Pathobiology, New York University College of Dentistry, New York City, USA
8:40 am - 9:30 amKeynote Lecture: 
Rosalind John (Cardiff University)
“Placental lactogen insufficiency impacts maternal caregiving and offspring behaviour”
9:30 am - 9:40 amBreak
9:40 am - 12:20 pmSymposium 1 Sexual dimorphism in the GH/PRL systems
Chairs: Stephen Bunn (University of Otago) and Kristina Smiley (University of Otago)
 Valerie Gouon-Evans (Boston University)
"GH activates regeneration in the sexually dimorphic acetaminophen mouse liver injury model"
 Guoli Dai (Indiana University Perdue University Indianapolis)
“Prolactin Receptor Signaling in Liver Health and Disease”
 Allison J Richard (Pennington Biomedical Research Center)
"Reduction of adipocyte STAT5, a primary mediator of GH action, confers sexually dimorphic responses in mice"
 Group Q&A
 Frank Porreca (University of Arizona)
“Uncovering a neuroendocrine link to female-selective pain and migraine”
 Gregory Dussor (University of Texas, Dallas)
“Sexually dimorphic effects of prolactin in preclinical models of migraine”.
 Teodora Georgescu (University of Otago, Dunedin, New Zealand)
"Prolactin acts on glutamatergic neurons in the ventromedial nucleus of the hypothalamus to modulate maternal aggression” 
 Stefanos Stagkourakis (Caltech)
"Control of maternal aggression via maternal hormone-sensitive hypothalamic neurons" 
 Group Q&A
12:20 pm - 2:00 pmInformal Programming:
Meet the Speaker Roundtables
Social Roundtables
Posters available throughout meeting
2:00 pm - 4:40 pmSymposium 2: Metabolism
Chairs: Rhonda Kineman (University of Illinois) and Jose Donato Junior (University of Sao Paulo)
 Jeff Zigman (University of Texas Southwestern Medical Center)
“Disrupting the ghrelin-growth hormone axis limits ghrelin’s orexigenic but not glucoregulatory actions”
 Shyuan T Ngo (Queensland Brain Institute, University of Queensland)
“Ghrelin/GH as a treatment for ALS” 
 Silvana Duran Ortiz (Ohio University)
"Lifespan Extension in Females and Improved Glucose Homeostasis in Mice with Disrupted GHR at 6 Months of Age" 
 Group Q&A
 Mercedes del Rio-Moreno (University of Illinois at Chicago)
"Adult-onset loss of hepatocyte GH receptor protects against diet-induced obesity and hyperinsulinemia, but exacerbates hepatic fibrosis and liver injury, independent of steatosis"
 Ronadip Banerjee (University of Alabama Birmingham Medical Center)
“Prolactin receptor-mediated actions in pancreatic islets during pregnancy”
 Felicitas López Vicchi (Instituto de Biología y Medicina Experimental, Buenos Aires, Argentina)
"Hyperprolactinemia exacerbates high-fat diet-induced adiposity, brown adipose tissue whitening, and impairment of glucose homeostasis"
 Tiffany Miles (University of Arkansas for Medical Sciences)
"Single-Cell Genomics of Somatotropes and Lactotropes in Female FVB Mice following a high fat diet (HFD)"
 Group Q&A
4:40 pm - 7:00 pmInformal Programming:
Meet the Speaker Roundtables
Social Roundtables
Posters available throughout meeting
7:00 pm - 9:40 pmSymposium 3 Neuroendocrine Regulation of GH and PRL
Chairs: Paul LeTissier (University of Edinburgh) and Renata Frazão (University of São Paulo) 
 Jimena Ferraris (Stockholm University, Sweden)
"Effects of Estrogen on Tuberoinfundibular Dopamine (TIDA) Neurons: A novel substrate for sex hormone regulation of prolactin secretion"
 Joe Yip (University of Otago, New Zealand)
“Prolactin-induced switch in neurohormone secretion in maternal brain”
 Ana Clara Campideli (Federal University of Minas Gerais, Brazil)
“Selective loss of KNDy neurons in female rats reveals multiple roles in gonadal and prolactin axes”
 Group Q&A
 Holly Phillips (Centre for Neuroendocrinology, University of Otago)
“Role of prolactin-induced Insulin-like growth factor 2 (Igf2) in the subventricular zone neurogenic niche”
 Ferran (Fernando) Martinez-Garcia (Universitat Jaume I, Spain)
"Lactogens in the brain during motherhood might enhance maternal motivation for pup stimuli"
 Judith Swart (University of Otago)
“Prolactin influences the reward associated with maternal interactions with pups”
 Vivien Csikós (Eötvös Loránd University, Budapest, Hungary)
"The role of microglia in the regulation of prolactin release"
 Group Q&A


Day 2: May 19, 2021

Time (Eastern)Event
8:30 am - 8:40 amIntroduction and notices (David Grattan, Chair, Organising Committee)
8:40 am - 9:30 amKeynote Lecture
Chair: Darlene Berryman (Ohio University)

Shlomo Melmed
(Cedars-Sinai Medical Center)
“Does GH cause cancer?”
9:30 am - 12:20 pmSymposium 4 Growth
Chairs: Laura Dichtel (Harvard University) and Rebecca Dumbell (Nottingham Trent University, UK)
 Jens O.L. Jørgensen (Aarhus University)
“Tools to unravel GH effects in vivo: from acipimox to acromegaly”
 Peter Clayton (University of Manchester, UK)
“Gene expression signatures predict response to therapy with growth hormone”
 Tim Wells (University of Cardiff)
"Eat less and grow just the same: the impact of meal-feeding on GH axis activity in male rodents" 
 Group Q&A
 Dayana Abboud (University of Leige, Belgium)
“GPR101 drives growth hormone hypersecretion and gigantism via constitutive activation of Gs and Gq/11” 
 Arne Hinrichs (Ludwig-Maximilians University, Munich, Germany)
“Growth Hormone Receptor-deficient pigs – a large animal model for Laron Syndrome”   
 Jonathan Young (Ohio University)
"Cross-species comparison of adipose tissue morphology and gene expression in GH resistance"
 Renata Frazão (University of Sao Paulo)
"Hypothalamic kisspeptin system is not compromised due to Growth hormone deficiency"
 Group Q&A
12:20 pm - 2:00 pmInformal Programming:
Meet the Speaker Roundtables
Social Roundtables
Posters available throughout meeting
2:00 pm - 4:40 pmSymposium 5  Target organs and signal transduction
Chair: Jakob Treibel (Nürnberg, Germany) and Leonard Cheung (University of Michigan)
 Shoshana Yakar (New York University)
“Insulin-like growth factors and bone”
 John-Olov Jansson (Gothenburg University, Sweden)
“The gravitostat hypothesis for regulation of prepubertal growth”
 Soraia Macari (Federal University of Minas Gerais, Brazil)
“Prolactin effects on bone during lactation”
 Manisha Dixit (NYU College of Dentistry)
"Uncoupling excess GH and serum IGF-1 compromises bone morphology and bone quality"
 Group Q&A
 Hye Kyung Lee (NIH, Bethesda)
“JAK/STAT enhancers control cell-specific gene expression: from caseins to the SARS-CoV-2 receptor ACE2”
 Georgina Ortiz (Universidad Nacional Autónoma de México (UNAM))
"Vasoinhibin is generated during and protects against murine inflammatory arthritis by reducing angiogenesis and vaopermiability of the pannus"
 Josephine Trott (University of California, Davis)
"Increased pork production efficiency through manipulation and understanding of the actions of prolactin"
 Stanislav Cherepanov (University of Montpellier)
"Functional analysis of prolactin-sensitive networks in the arcuate nucleus"
 Group Q&A
4:40 pm - 6:00 pmInformal Programming:
Meet the Speaker Roundtables
Social Roundtables
Posters available throughout meeting
6:00 pm - 8:16 pmSymposium 6 Cancer
Chairs: Vincent Goffin (INSERM, Paris) and Jo Perry (University of Auckland) 
 Reeto Basu (Ohio University)
“Improving anti-cancer drug efficacy by combining growth hormone receptor antagonism”
 Yanrong Qian (Ohio University)
"Growth Hormone Receptor Antagonist Sensitizes Melanoma and Hepatocarcinoma to Drug Treatments via Downregulation of ATP-Binding Cassette Transporters"
 Prateek Kulkarni (Edison Biotechnology Institute, Ohio University)
"Growth Hormone Modulates Multi-Drug Efflux Pumps in Melanoma-Derived Exosomes"
 Group Q&A
 Ameae Walker (University of California, Riverside)
“Prolactin-immune Interactions in Breast Cancer”
 Justin Craig (Virginia Commonwealth University)
"Prolactin Drives a Dynamic STAT5A/HDAC6/HMGN2 Cis-Regulatory Landscape Exploitable in ER+ Breast Cancer"
 Jacqueline Grible, Charles Clevenger (Virginia Commonwealth University)
"The intermediate prolactin receptor is a mammary proto-oncogene"
 Group Q&A
8:16 pmClosing Remarks
Dave Grattan, Darlene Berryman, Shoshana Yakar (Chairs, Organising Committee)