Please note that all times listed currently reflect US Eastern Time (ET). The schedule is subject to change. Presentations are pre-recorded followed by live Q&A.

Day 1: Tuesday, June 15, 2021

10:00 am – 10:10 amWelcome: 
Vera Gorbunova, Andreas Guse, Raul Mostoslavsky, & W. Lee Kraus
10:10 am – 10:35 amNAD + Signaling Keynote #1: Organellar Ca2+ regulators (OCaRs) determining NAADP-mediated Ca2+ release from acidic intracellular stores in pancreatic acinar cells and cardiomyocytes
 Marc Freichel
(Heidelberg University)
10:35 am – 10:50 amShort Talk #1: NAADP forming enzyme in T cells
Feng Gu (University Medical Center Hamburg- Eppendorf)
10:50 am – 11:05 amShort Talk #2: HN1L/JPT2: a signaling protein connecting NAADP to Ca2+ microdomains
Imrankhan Khansahib (University Medical Center Hamburg-Eppendorf
11:05 am – 11:20 amShort Talk #3: The rodenticide vacor induces activation of SARM1 by generation of a cytotoxic NAD analog in the nicotinamide salvage pathway
Lars Sverkeli (University  of Bergen)
11:20 am – 11:35 amShort Talk #4: Discovery and applications of a novel fluorescent probe of SARM1
Yongjuan Zhao (The Chinese University of Hong Kong (Shenzhen))
11:35 am – 12:00 pmKeynote #2: Ligand recognition and gating mechanism of ADP ribose-sensitive TRPM2 channel
 Juan Du (early career)
(Van Andel Institute)
12:05 pm – 2:00 pmPoster Session
2:00 pm – 2:25 pmPoly(ADP-ribosyl)ation and PARPs Keynote #1: Mono-ADP-ribosylation controls specific membrane transport routes
 Daniela Corda 
(National Research Council of Italy)
2:25 pm – 2:40 pmShort Talk #1: Chemical Proteomics Approach for Profiling the NAD Interactome
 Sunil Sundalam/Michael Cohen 
(Oregon Health & Science University)
2:40 pm – 2:55 pmShort Talk #2: Skeletal muscle Poly-ADP-Ribose Polymerase 1 (PARP1) ablation or inhibition decreases skeletal muscle mass and muscle fiber size
Alexander Green (University of Ottawa)
2:55 pm – 3:10 pmShort Talk #3: Alphavirus ADP-ribosylhydrolase Activity Controls Stress Granule Dynamics
Aravinthkumar Jayabalan (Johns Hopkins University)
3:10 pm – 3:25 pmShort Talk #4: Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
Johannes Rack (University of Oxford)
3:25 pm – 3:50 pmKeynote #2: Serine ADP-ribosylation by HPF1/PARP1 as a versatile technology for exploring multiple ADPr signals  
 Ivan Matic (early career)
(Max Planck Institute for Biology of Ageing)
4:00 pm – 5:00 pmMeet the Editors - Rosalind Mott, Cell Metabolism; Christoph Schmitt, Nature Metabolism


Day 2: Wednesday, June 16, 2021

10:00 am – 10:10 amWelcome:
Vera Gorbunova, Andreas Guse, Raul Mostoslavsky, & W. Lee Kraus 
10:10 am – 10:35 amSirtuins Keynote #1: David Sinclair (Harvard University)
10:35 am – 10:50 amShort Talk #1: NADH-SIRT1 Redox Axis Controls Transcription and Rhythmic Metabolism
Daniel Levine (Northwestern University)
10:50 am – 11:05 amShort Talk #2: The balance between SIRT6-mediated DNA repair and LINE1-suppression controls resistance to DNA damage and lifespan in mice
Matt Simon (University of Rochester)
11:05 am – 11:20 amShort Talk #3: A centenarian variant of SIRT6 enhances genome maintenance activity
Jonathan Gigas/Andrei Seluanov (University of Rochester)
11:20 am – 11:35 amShort Talk #4: Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
Andrey Nikiforov (Institute of Cytology, Russian Academy of Sciences)
11:35 am – 12:00 pmKeynote #2: SIRT6 in DNA repair and  age-related disease
Debbie Toiber (early career) (Ben Gurion University of the Negev)
12:05 pm – 1:00 pmMeet the Speakers
1:00 pm – 2:00 pmROUNDTABLE DISCUSSION: Benefits of Joining a Scientific Professional Society – Joining a scientific professional society offers many benefits beyond discounted meeting registration rates and journal subscriptions. This discussion will explore how joining a society helps scientists build their network, find mentors, explore professional development opportunities, advance their career, and give back to their profession. It will also provide tips for maximizing the value of your membership in a society. HOST: Mary-Ann Bjornsti, PhD, FASEB Vice President-Elect for Science Policy/ University of Alabama at Birmingham
2:00 pm – 2:25 pmMetabolism and Interventions Keynote #1: Shin Imai (Washington University)
2:25 pm – 2:40 pmShort Talk #1: Evolution of histone-mediated compartmental regulation of NAD metabolism
 Iva Guberovic/Marcus Buschbeck 
(Josep Carreras Leukaemia Research Institute)
2:40 pm – 2:55 pmShort Talk #2: NAD precursors cycle between host tissues and the gut microbiome
Karthikeyani Chellappa (University of Pennsylvania)
2:55 pm – 3:10 pmShort Talk #3: MCART1/SLC25A51 is required for mitochondrial NAD transport
Nora Kory (Harvard T.H. Chan School of Public Health
3:10 pm – 3:25 pmShort Talk #4: Improved liver regeneration following nicotinamide riboside supplementation requires hepatocyte lipolysis
Sarmistha Mukherjee (University of Pennsylvania)
3:25 pm – 3:50 pmKeynote #2: Compartmentalized Regulation of Intracellular NAD+
Lulu Cambronne (early career) (University of Texas at Austin)
4:00 pm – 5:00 pmSocial Hour