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Protein Aggregation in Health and Disease

Conference Summary

This SRC is focused on protein aggregation, which plays central roles in health and in disease and a converged understanding of these dual roles is absolutely essential if we are to understand the emergence of biological complexity and the onset and progression of devastating systemic and neurodegenerative diseases. Importantly, protein aggregation and aggregates are also central in numerous biological functions as is evidenced in the growing number of accounts of functional aggregates and their roles in fungi, bacteria, and in the innate immune system of humans. Recent studies have highlighted the role of phase separation driven by a form of protein aggregation that gives rise to functional, non-stoichiometric assemblies, known as membraneless organelles.

The intent of this meeting is to bring together scientists working on biophysical and biological aspects of protein aggregation and connect physical understand of aggregation to its biological consequences in post mitotic cells. The conference will begin with keynote talks by two leading figures, Dr. Virginia Lee and Dr. Sheena Radford. Their talks will highlight the translational aspects and biophysical underpinnings of protein aggregation.

The remainder of the conference will be organized around specific thematic sessions that focus on specific proteins or collections of proteins and work up to uncovering the impact of protein aggregation on cellular processes and disease states. This conference will span a range of topics. These include a discussion of emerging technologies to study protein aggregation in vitro and in cells, advancements in our understanding of cellular stresses induced by protein aggregation, our ability to target the stress response pathways therapeutically as a route to finding cures for devastating neurological and systemic diseases, routes that connect aggregation mechanisms and specific aggregates to disease, methods to target aggregation or particular species in order to cure disease, the emerging synergy between protein aggregation and phase separation in the context of form liquid-like membraneless bodies within cells, and the functional role of protein aggregates, a theme that continues to be paradigm shifting in biology. Taken together these sessions will give the participants an integrative view of protein aggregation and the impact it has on health and disease.

The cross-disciplinary nature of the conference is accentuated by the program, which brings together biophysicists, structural biologists, and bioengineers with cell biologists and clinical scientists.

Program Agenda


Important Deadlines:   Early Bird: May 3, 2017         Last Day to Register: May 11, 2017


Highlights

  • Career Development Panel, featuring academic and industry leaders, presenting their thoughts in a Town Hall format.
  • Short talks will be selected from submitted abstracts
  • Meet the Expert sessions

Keynote Speaker

Dr. Virginia Lee
University of Pennsylvania

Dr. Sheena Radford
University of Leeds

Conference Organizers

Rohit V. Pappu
Washington University in St. Louis
pappu@wustl.edu

Christina Sigurdson
University of California San Diego
csigurdson@ucsd.edu

Conference Staff

Kristen Hagy, CMP, Conference Manager

Pippa O'Shea, Conference Assistant

Contact us:
Email: src@faseb.org
Phone: 1.301.634.7010

Date & Location

Date: June 11-16, 2017
Location:
The Steamboat Grand
2300 Mt. Werner Circle
Steamboat Springs, CO

Transportation & Lodging

Airport Information

The Steamboat Grand Resort is 22 miles from the Steamboat-Yampa Valley Regional/Hayden Airport (HDN) and 155 miles northwest of Denver International Airport (DIA).  Please note, Hayden Airport is a regional airport and only offers two flights per day during the summer months

Click the links below for Transportation & Lodging information:

Official Conference Lodging

The Steamboat Grand
2300 Mt. Werner Circle
Steamboat Springs, CO 80487-9027
970.871.5050

If you request a single or a double occupancy room, the registration fee covers 5 nights of lodging (Sunday through Thursday night, checkout Friday morning). A credit card will be required upon check-in for incidental expenses (i.e. in-room movies, room service, etc.).

If you plan to arrive early or stay beyond the conference dates, you must make your own reservations for the extra nights you require. You are responsible for payment upon check-out.

Click here for additional Offsite Lodging.