This FASEB SRC focuses on protein phosphatases, essential components of phosphorylation-based regulatory networks, which control virtually all biological processes. This is an exciting time in protein phosphatase research. New insights into the actions of individual protein phosphatases are being directly connected to pathophysiological outcomes, and phosphatase-directed therapeutics are in rapid development.
This conference unites a dynamic international community of researchers from all levels of academia and industry around shared interests in phosphatases, while highlighting diverse perspectives and approaches to their study: from basic to translational research, and from cell and systems biology to biochemistry and structural biology. The program will link detailed understanding of phosphatase structure and mechanism to control of basic cellular processes, i.e. cell proliferation, migration and metabolism, in healthy and diseased cells. Recent successes in therapeutic targeting of phosphatases will be highlighted.
Conference sessions will explore new methods for investigating protein phosphatases and their signaling networks, and will highlight the latest discoveries concerning phosphatases that target phosphothreonine, phosphoserine, phosphotyrosine or phosphohistidine residues. Recent findings reveal new roles for these enzymes in regulating basic metabolic and cell biological processes in the nervous and immune systems. A major focus for the meeting is elucidating protein phosphatase function and perturbation in disease especially cancer. Drug development efforts to treat cancer, auto-immune and neurodegenerative disorders, and diabetes by either activating or inhibiting phosphatases will be discussed. The conference will highlight new areas of investigation, and researchers that are new to the field or want to educate themselves about these enzymes are encouraged to attend. The meeting will take place in Snowmass, Colorado, a beautiful setting that promotes both formal and informal interactions between conference attendees.
Dr. Nick Tonks, who discovered phosphotyrosine phosphatases thirty years ago and continues to lead breakthroughs in their study, will deliver the conference’s keynote address. Platform and poster sessions will cover the latest in phosphoproteomic, systems and structural studies of phosphatases, emerging research in their regulation of gene expression, cell division cycle and cytoskeleton, and investigations of phosphatase function in different physiological contexts ranging from hematopoietic cells to neurons. Invited presentations given by experts in the field, will be combined with short talks chosen from submitted abstracts. Meet the expert sessions and a career development event are offered to stimulate interactions between senior and junior investigators.