This FASEB SRC addresses the process of how proteins acquire their beautiful three-dimensional structures, required for functionality. Protein folding has been studied for decades in the test tube, and while this approach continues to aid our understanding of the fundamental physical and chemical forces that govern folding, there has been a concomitant and growing appreciation that the cellular environment presents unique challenges – as well as unique support systems – that cannot be easily captured in the test tube. Understanding how proteins fold and why they misfold are major goals in the quest to understand the mechanisms of the cellular protein quality control machineries, The knowledge gained will help us to find strategies to correct misfolding diseases, which include Alzheimer’s and cystic fibrosis.
This SRC is devoted to bridging the gap between understanding how proteins fold and the consequences for the cell when they misfold. The goals of the conference are to: (1) Facilitate new collaborations amongst scientists in diverse disciplines who study protein folding and aggregation; (2) Stimulate new scientific directions by exposing investigators to emerging concepts and technologies; and to (3) Develop new approaches to identify and treat diseases arising from defects in protein conformation.
Protein Folding in the Cell brings together the very best people from both academic and industry backgrounds who study the cellular and biophysical aspects of the protein folding problem. With so many great minds from such a broad range of institutions, there will be riveting discussion of the relationship between protein folding, cellular homeostasis, stress, and disease.
This meeting will feature several newly trending topics and themes in the scientific program, presented by internationally recognized leaders in their respective areas. In particular, there will be sessions about folding and aging, chaperone mechanisms, protein triage and degradation, aggregates and assemblies, how diseases affect folding, organellar specific folding issues and of course, folding in the cell. Attendees will be given the opportunity to orally present their research to the whole group. In addition to invited speakers, ~ 15 additional speakers will be selected based on submitted abstracts to present 12 minute talks. Every poster presenter will also have the opportunity to introduce their poster with a 2 minute, one slide talk. Six monetary prizes will be awarded to the most effective short and lightning talks, as decided by audience vote.