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GRKs and Arrestins: From Structure to Disease

Conference Summary

This SRC provides an interactive forum to discuss current developments in the G protein-coupled receptor (GPCR) field with a particular focus on GPCR kinases (GRKs) and arrestins.  GRKs and arrestins work together to regulate GPCR signaling by reducing the ability of receptors to couple with heterotrimeric G proteins and by targeting active receptors for endocytosis. These mechanisms are important for returning cells to their physiological resting states. In addition, GRKs and arrestins are also thought to initiate alternative signaling pathways and to play prominent roles in addiction, cardiovascular disease and other pathological conditions. Consequently there is a major effort to identify small molecules that bias GPCRs for or against GRK/arrestin-mediated pathways or that prevent overcompensation by GRKs and arrestins.

The overarching goal of the meeting is to bring together as many scientists working on diverse aspects of GRK/arrestin signaling as possible, in order to facilitate the exchange of novel findings and to stimulate the generation of new hypotheses, collaborations and approaches. The structural and functional mechanisms of GRKs and arrestins, as well as their roles in biased/non-canonical signaling by GPCRs, in the actions of drugs of abuse, in cardiovascular disease and in cancer will be major highlights of the meeting. Sessions devoted to these topics will foster further studies to combat addiction and disease with the ultimate objective of positively influencing human health. There are many opportunities available for attendees to give oral and poster presentations as well as optional recreational activities to foster the exchange of ideas and formulate new collaborations.

Program Agenda


Important Deadlines:   Early Bird: May 3, 2017
                                       Last Day to Register Extended To: May 19, 2017


Highlights

  • Keynote Addresses by Nobel Laureates Drs. Robert J. Lefkowitz and Brian Kobilka
  • Career Development Workshop
  • Meet the Expert sessions

Keynote Speakers

Robert J Lefkowitz
Duke University School of Medicine

Brian K Kobilka
Stanford University School of Medicine

Conference Organizers

Jeffrey Benovic
Thomas Jefferson University
jeffrey.benovic@jefferson.edu

Federico Mayor, Jr.
Universidad Autónoma Madrid- Centro de Biología Molecular "Severo Ochoa"
fmayor@cbm.csic.es

John Tesmer
University of Michigan
tesmerjj@umich.edu

Conference Staff

Trina Eacho, Conference Coordinator

Pippa O'Shea, Conference Assistant

Contact us:
Email: src@faseb.org
Phone: 1.301.634.7010

Date & Location

Date: June 11-16, 2017
Location:
Horowitz Performing Arts Hall and Nita Choukas Theater
10 Long Walk
Saxtons River, VT

Transportation & Lodging

Airport Information

Vermont Academy in Saxtons River, Vermont is 130 miles from Logan International Airport (BOS) in Boston, Massachusetts and 110 miles from Bradley International Airport (BDL) near Hartford, Connecticut.

Click the links below for Transportation & Lodging information:

Official Conference Lodging

Vermont Academy
10 Long Walk
Saxtons River, VT 05154-0500
802.869.6229

The sleeping rooms at Vermont Academy are dormitory style rooms with shared bathrooms. The rooms are not air conditioned, fans are provided. You may request a key for your room with a $20 refundable deposit.

Click here for additional Offsite Lodging.