One-carbon metabolism and related dietary factors (folic acid and vitamin B12, as well as vitamin B6, choline, riboflavin, methionine, serine, cysteine, and others) play important roles in a vast array of essential physiological functions. Disruptions of one-carbon metabolism due to dietary, pharmacological, environmental, and genetic factors impact most of the major health issues of our time, including vascular disease, cancer, neurodegenerative disease (Alzheimer’s disease and dementia, Parkinson’s disease), birth defects, and comorbidities associated with obesity and diabetes such as renal disease. The “Folic Acid, Vitamin B12, and One-Carbon Metabolism” SRC has been meeting every other year since the mid-1980s. From its inception, the conference has embraced an integrative philosophy that brings together basic researchers, physician scientists, and policy makers to share cutting edge research and to discuss its ramifications for health at both the personal and population levels. For 2018, in addition to updates on new findings related to the fundamental biochemistry of folates, B12, and one-carbon metabolism, session topics will focus on 1) Vitamin B12 transporters: binders, receptors & chaperones, 2) Oxidative stress, one-carbon metabolism and development, 3) In utero effects of disruption in one-carbon metabolism, 4) One-Carbon metabolism and neurodegenerative disease, 5) Choline – The good, the bad and the ugly, 6) Interactions between pharmacologic agents, xenobiotics and 1C metabolism, 7) Novel aspects of transsulfuration, and 8) The many faces of MTHFR. Conference attendees can expect thought-provoking oral communications from leaders in the field, stimulating discussions during questions and answers sessions and expanded opportunities for students and post-doctoral trainees to present their work in both oral and poster sessions, as well as formal and informal opportunities to exchange ideas and establish new collaborations.