This SRC focuses on the endoplasmic reticulum (ER) and its functions. The purpose of the meeting is to merge recent developments in molecular biology, cell biology, genetics, and physiology aimed at unraveling the complexities of secretory protein folding, ER stress pathways, lipid signaling, and ER membrane biology, and how failure of these processes lead to pathologies and disease. This SRC will include talks from outstanding scientists, both invited and selected from poster abstracts. The meeting is known for its active discussions, not only during the presentation session, but also during the free afternoons, and especially during the poster sessions. Posters will remain on display during most of the conference and a selection will be advertised in oral poster pitches. The venue, Vermont Academy, is excellently suited for the mingling of junior and established scientists, which will be strengthened by meet-the-speaker sessions that allow discussions of both career issues and science.