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Functional Disulfide Bonds in Health and Disease

Conference Summary

Most proteins are chemically modified after they are made to control how, when, and where they function. It was thought that only the amino acid side chains and the peptide bonds of proteins were chemically modified. It has become clear in recent years that the disulfide bonds of proteins are also modified. Some disulphide bonds are cleaved in the mature protein to control function. From a few examples a decade ago, there are now about thirty well defined examples of control of protein function by functional disulfides and dozens more examples that are under investigation. Cleavage of a functional disulfide in a protein changes the bioactivity of the protein. Changes in ligand binding, substrate hydrolysis, proteolysis, or oligomer formation have been described. The functional disulfides are cleaved by reductases or by thiol–disulfide exchange. Viral, bacterial, plant and mammalian proteins have been found to be regulated by functional disulfides, so this mechanism of protein control operates in all life forms. The early indications are that cleavage of disulphide bonds may rival proteolysis of peptide bonds as a means of protein control.

This conference will focus on the functional disulfides that contribute to regulation of thrombosis, inflammation and immunity in mammals. How protein function in these systems is regulated by disulfide bond cleavage and the factors that cleave the bonds will be discussed. The chemistry and molecular dynamics of cleavage of functional disulfides will be addressed, and the bioinformatic and experimental approaches used to identify and study these bonds will be examined. Some functional disulfides have been linked to human disease and progress is being made on ways of targeting these bonds for new diagnostics and therapies. Small molecule inhibitors of the factors that cleave functional disulfides are in pre-clinical and clinical development.

The invited presentations will be from both established and junior investigators and a large number of oral presentations will be selected from the abstracts. The talks, poster presentations and recreational activities will provide students and postdoctoral fellows with opportunities to exchange ideas, formulate new collaborations and explore career options in this research field.

View the Program Agenda

Important Deadlines: Early Bird: June 30, 2016       

Last Day to Register Extended: July 21, 2016

Highlights

  • Functional disulfides that contribute to regulation of thrombosis, inflammation and immunity in mammals will be highlighted.
  • How to identify and study functional disulfides.
  • How to target functional disulfides for new diagnostics and therapies for disease.

Keynotes/VIP Speakers

Dr Arne Holmgren
Karolinska Institute, Sweden

Dr Jon Beckwith
Harvard University, USA

Dr Peter Cresswell
Yale University, USA

Dr Julio Fernandez
Columbia University, USA

Dr Chaitan Khosla
Stanford University, USA

Conference Organizers

Dr Philip Hogg
University of Sydney
philip.hogg@ctc.usyd.edu.au

Dr Bruce Furie
Beth Israel Deaconess Medical Center
bfurie@bidmc.harvard.edu

Dr Barry Coller
Rockefeller University
collerb@rockefeller.edu

Conference Staff

Robin Crawford, CMP, Conference Manager
Pippa O'Shea, Conference Assistant

Contact us:
Email:  src@faseb.org   Phone: 1.301.634.7010


Date & Location

Date: August 14-17, 2016
Location: The Steamboat Grand
                 2300 Mt. Werner Circle
                 Steamboat Springs, CO

Transportation & Lodging

Airport Information

The Steamboat Grand Resort is 22 miles from the Steamboat-Yampa Valley Regional/Hayden Airport (HDN) and 155 miles northwest of Denver International Airport (DIA).  Please note, Hayden Airport is a regional airport and only offers two flights per day during the summer months

Click the links below for Transportation & Lodging information:

Official Conference Lodging

The Steamboat Grand
2300 Mt. Werner Circle
Steamboat Springs, CO
970.871.5050

If you request a single or a double occupancy room, the registration fee covers 5 nights of lodging (Sunday through Thursday night, checkout Friday morning). A credit card will be required upon check-in for incidental expenses (i.e. in-room movies, room service, etc.)

If you plan to arrive early or stay beyond the conference dates, you must make your own reservations for the extra nights you require. You are responsible for payment upon check-out.

Click here for additional Offsite Lodging.