Biological Methylation: Fundamental Mechanisms in Health and Disease

Conference Summary

This SRC is focused on  the role of Methylation Dynamics in nuclear and cytoplasmic biological processes and how this modification impacts development, epigenetic cellular identity, tissue homeostasis and disease. Studies looking at how this chemical modification impacts nucleic acid and protein function across model systems and in disease models will be presented. These topics will be complemented with presentations on how methylation states are established, maintained, interpreted and inter-converted, along with their functional cellular consequences  and how this translates into developmental and disease states. Since methylation has become a major therapeutic target in recent years, there will be a focus on the advancements in therapeutics and technologies used to quantitatively monitor this modification in cells and organisms.

This meeting will bring together an interdisciplinary group of scientists interested in how a small covalent modification can have such profound biological impact.  Invited speakers are experts in biological methylation from a variety of perspectives including cell and developmental biology, molecular biology, epigenetics/epigenomics,  structural biology and chemical biology.  The conference will be structured to optimize interactions among all attendees, with several poster sessions and technology workshops. A significant number of oral presentations will be chosen from poster abstracts submitted by trainees and junior faculty.  This conference will also be an excellent opportunity for scientists less familiar with methylation mediated signaling and epigenetics to learn how this rapidly evolving field could impact their research. 

View the Program Agenda

Important Deadlines:  Early Bird: May 5, 2016         Last Day to Register: May 20, 2016 


  • Survey of the latest research results and conceptual understanding of  fundamental mechanisms of protein, DNA and RNA methylation and demethylation, especially as relates to regulation of gene expression programs.
  • Update on the current understanding of the role of biological methylation in human disease, especially cancer and inflammation.
  • Presentations and workshops highlighting the latest technologies and methodologies for studying biological methylation in cells, tissues and organisms.

Keynote Speakers

Peter Jones, Van Andel Research Institute
Geneviéve Almouzni, Institut Curie

Conference Organizers

Cheryl Arrowsmith
Princess Margaret Cancer Centre and University of Toronto

Johnathan R. Whetstine, PhD
Harvard Medical School and Massachusetts General Hospital Cancer Center

Conference Staff

Kristen Hagy, CMP, Conference Manager
Pippa O'Shea
, Conference Assistant

Contact us:
Email: src@faseb.org   Phone: 1.301.634.7010

Date & Location

Date: June 19-24, 2016
Location: Lisbon Marriott Hotel 
                 Avenida dos Combatentes
                 Lisboa (Lisbon) 1600-042 Portugal

Transportation & Lodging

Airport Information

The closest airport is the Lisbon Portela Airport (LIS), which is 4.3 miles or 6.9 kilometers from the Lisbon Marriott Hotel. Please visit the LIS site for more information.

Taxis and rental cars are available. Please use the links below for Transportation & Lodging information:

Official Conference Lodging

Lisbon Marriott Hotel
Avenida dos Combatentes
Lisboa (Lisbon) 1600-042 Portugal

The Lisbon Marriott Hotel is located in the new financial district. Guestrooms include 1 king or 2 twin beds, an in-room safe, LCD screen TV, voicemail, and air-conditioning. The hotel facilities include a fitness center and pool.

If you request a single or a double occupancy room, the registration fee covers 5 nights of lodging (Sunday through Thursday night, checkout Friday morning). A credit card will be required upon check-in for incidental expenses (i.e. in-room movies, room service, etc.)

If you plan to arrive early or stay beyond the conference dates, you must make your own reservations for the extra nights you require. You are responsible for payment upon check-out.

Click here for additional Offsite Lodging.