Abl-associated signaling and gene expression profiling: an assay by Drosophila cDNA microarray. S.S. Jiang* ¹, T.-Y. Lin ^1,2, M.-H. Wu ¹, Q.-S. Hong ³, H.-M. Lee ¹, Y.-M. Lee ⁴, J.-L. Juang ¹. 1) Division of Molecular and Genomic Medicine Research, National Health Research Institutes, Taipei, Taiwan; 2) Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan; 3) Department of Public Health, National Taiwan University, Taipei, Taiwan; 4) Department of Horticulture, National Taiwan University, Taipei, Taiwan.

   Abl was originally identified as the cellular homologue of the v-Abl oncogene of the Abelson murine leukemia virus and has been cloned from human, mouse, Drosophila, and nematode. Several functional domains of the Abl, including SH2, SH3, NLS, NES, and kinase domain had been characterized. Abl proteins are distributed through the nucleus and the cytoplasm, where they play distinct roles. The cellular roles of Abl kinase are mediated via multiple protein-protein or protein-DNA interactions. In order to gain insights into the Abl-regulated pathways, cDNA microarrays prepared from the 5,800 DGC (Drosophila Gene Collection) unigenes were used to analyze the Abl-related gene expression patterns in either cell lines or fruitflies. The results and its implication will be discussed.