Probing for Suppressors of D-APC Loss-of-Function Phenotype in Drosophila melanogaster. B.P Hafler , Y.F. Ahmed , E.F. Wieschaus. Molecular Biology, Princeton University, Princeton, NJ.

   Loss of D-APC, a Drosophila homolog of the adenomatous polyposis coli (APC) tumor suppressor results in neuronal apoptosis during retinal development. A decrease in levels of Armadillo and dTCF prevents apoptosis in the D-APC mutant, suggesting that D-APC functions to negatively regulate transcriptional activation by the Arm/dTCF complex. To identify other genes that interact with D-APC, we are conducting a mutagenesis screen for suppressors of the D-APC mutant phenotype. Characterization of suppressors of D-APC will be presented.